Evidence map›Paper›PMID 26589303›Full record

ArticlePediatric radiology2016

Development of a screening MRI for infants at risk for abusive head trauma.

Lynda Flom, Janet Fromkin, Ashok Panigrahy, Elizabeth Tyler-Kabara, Rachel P Berger

Open access · greenAbstract readValidation Study
In one paragraph

Article in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  5. Focused Abbreviated Survey MRI Protocols for Brain and Spine Imaging.Radiographics : a review publication of the Radiological Society of North America, Inc · 2023
    Article
  6. Abusive Head Trauma Animal Models: Focus on Biomarkers.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Imaging of Abusive Head Trauma : A Radiologists' Perspective.Journal of Korean Neurosurgical Society · 2022
    Article
  9. Parenchymal Insults in Abuse-A Potential Key to Diagnosis.Diagnostics (Basel, Switzerland) · 2022
    Review
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lynda FlomDepartment of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
Janet FromkinDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, 4401 Penn Ave., Pittsburgh, PA, 15224, USA.
Ashok PanigrahyDepartment of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
Elizabeth Tyler-KabaraDepartment of Neurosurgery, Children's Hospital of Pittsburgh of UPMC, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Rachel P BergerDepartment of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, 4401 Penn Ave., Pittsburgh, PA, 15224, USA. Rachel.berger@chp.edu.
Children's Hospital of Pittsburgh · USUniversity of Pittsburgh · USMcGowan Institute for Regenerative Medicine · US

Funding

Novel Approaches to Screening for Inflicted Childhood NeurotraumaR01HD055986 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BERGER, RACHEL P · 2009 to 2014
$2.8M
NICHD NIH HHS R01 HD055986NICHD NIH HHS R01HD055986
6 · The paper itself

Abstract

backgroundAbusive head trauma (AHT) is an important cause of morbidity in infants. Identifying which well-appearing infants are at risk for AHT and need neuroimaging is challenging, and concern about radiation exposure limits the use of head CT. Availability of an MRI protocol that is highly sensitive for intracranial hemorrhage would allow for AHT screening of well-appearing infants without exposing them to radiation.

objectiveTo develop a screening MRI protocol to identify intracranial hemorrhage in well-appearing infants at risk for AHT. MATERIALS AND

methodsInfants enrolled in a parent study of well-appearing infants at increased risk for AHT were eligible for the current study if they underwent both head CT and conventional brain MRI. A derivation cohort of nine infants with AHT was used to identify sequences that provided the highest sensitivity for intracranial hemorrhage. A validation cohort of 78 infants including both controls with normal neuroimaging and cases with AHT was used to evaluate the accuracy of the selected sequences.

resultsThree pulse sequences - axial T2, axial gradient recalled echo (GRE) and coronal T1-W inversion recovery - were 100% sensitive for intracranial hemorrhage in the derivation cohort. The same sequences were 100% sensitive (25/25) and 83% specific (44/53) for intracranial hemorrhage in the validation cohort.

conclusionA screening MRI protocol including axial T2, axial GRE and coronal T1-W inversion recovery sequences is highly sensitive for intracranial hemorrhage and may be useful as a screening tool to differentiate well-appearing infants at risk for AHT who should undergo head CT from those who can safely be discharged without head CT. Additional research is needed to evaluate the feasibility of this approach in clinical practice.

Indexed as

AlgorithmsChild AbuseCraniocerebral TraumaFemaleHumansImage EnhancementInfantInfant, NewbornMagnetic Resonance ImagingMaleMass ScreeningReproducibility of ResultsSensitivity and SpecificityUnited StatesAbusive head traumaBrainChild abuseInfantsMagnetic resonance imagingScreening

Identifiers

PMID26589303
PMCPMC4814308
OpenAlexW2175787540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.