ArticleBMC genomics2015
Transcriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominis.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Comprehensive analysis of small GTPases in Microsporidia reveals new extremes in eukaryotic cell biology.BMC biology · 2026Article
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- scRNA-seq uncovers the transcriptional dynamics of Encephalitozoon intestinalis parasites in human macrophages.Nature communications · 2025Article
- Polyploidy is widespread in Microsporidia.Microbiology spectrum · 2024Article
- The intracellular parasite Anncaliia algerae induces a massive miRNA down-regulation in human cells.Non-coding RNA research · 2023Article
- Morphological characterization and genetic diversity of a new microsporidium,Frontiers in cellular and infection microbiology · 2023Article
- Inhibition of mitosomal alternative oxidase causes lifecycle arrest of early-stage Trachipleistophora hominis meronts during intracellular infection of mammalian cells.PLoS pathogens · 2022Article
- Heterologous Expressed NbSWP12 from MicrosporidiaJournal of fungi (Basel, Switzerland) · 2022Article
- Generalist parasites persist in degraded environments: a lesson learned from microsporidian diversity in amphipods.Parasitology · 2022Article
- Microsporidia, a Highly Adaptive Organism and Its Host Expansion to Humans.Frontiers in cellular and infection microbiology · 2022Review
- Comparative Genomics of Microsporidia.Experientia supplementum (2012) · 2022Article
- Human microsporidian pathogenJournal of cell science · 2021Article
- Evolution of microsporidia: An extremely successful group of eukaryotic intracellular parasites.PLoS pathogens · 2020Article
- A new family of cell surface located purine transporters in Microsporidia and related fungal endoparasites.eLife · 2019Article
- Encephalitozoon cuniculi and Vittaforma corneae (Phylum Microsporidia) inhibit staurosporine-induced apoptosis in human THP-1 macrophages in vitro.Parasitology · 2019Article
- Microsporidian Introns Retained against a Background of Genome Reduction: Characterization of an Unusual Set of Introns.Genome biology and evolution · 2019Article
- Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites.Nature communications · 2018Article
- Effects of the vertically transmitted microsporidian Facilispora margolisi and the parasiticide emamectin benzoate on salmon lice (Lepeophtheirus salmonis).BMC genomics · 2017Article
- Evolutionary conservation and in vitro reconstitution of microsporidian iron-sulfur cluster biosynthesis.Nature communications · 2017Article
- Genome Analysis of Pseudoloma neurophilia: A Microsporidian Parasite of Zebrafish (Danio rerio).The Journal of eukaryotic microbiology · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTrachipleistophora hominis was isolated from an HIV/AIDS patient and is a member of a highly successful group of obligate intracellular parasites.
methodsHere we have investigated the evolution of the parasite and the interplay between host and parasite gene expression using transcriptomics of T. hominis-infected rabbit kidney cells.
resultsT. hominis has about 30% more genes than small-genome microsporidians. Highly expressed genes include those involved in growth, replication, defence against oxidative stress, and a large fraction of uncharacterised genes. Chaperones are also highly expressed and may buffer the deleterious effects of the large number of non-synonymous mutations observed in essential T. hominis genes. Host expression suggests a general cellular shutdown upon infection, but ATP, amino sugar and nucleotide sugar production appear enhanced, potentially providing the parasite with substrates it cannot make itself. Expression divergence of duplicated genes, including transporters used to acquire host metabolites, demonstrates ongoing functional diversification during microsporidian evolution. We identified overlapping transcription at more than 100 loci in the sparse T. hominis genome, demonstrating that this feature is not caused by genome compaction. The detection of additional transposons of insect origin strongly suggests that the natural host for T. hominis is an insect.
conclusionsOur results reveal that the evolution of contemporary microsporidian genomes is highly dynamic and innovative. Moreover, highly expressed T. hominis genes of unknown function include a cohort that are shared among all microsporidians, indicating that some strongly conserved features of the biology of these enormously successful parasites remain uncharacterised.
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