ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2015
Role of non-hepatotropic viruses in acute sporadic viral hepatitis and acute-on-chronic liver failure in adults.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Pharmacological Potential of Selenoproteins in the Regulation of Oxidative Stress in Liver Diseases.Pharmaceutics · 2026Review
- A global consensus on the critical care management of acute-on-chronic liver failure patients: the APASL ACLF Beijing Position Paper.Hepatology international · 2026Article
- Higher prevalence of cytomegalovirus and Epstein-Barr virus in acute-on-chronic liver failure.JHEP reports : innovation in hepatology · 2026Article
- mNGS improves the efficiency of infection diagnosis and treatment in acute-on-chronic liver failure.BMC gastroenterology · 2026Observational
- Non hepatotropic virus induced hepatitis - rising importance in a changing world.World journal of virology · 2025Review
- Rising incidence of acute hepatitis A among adults and clinical characteristics in a tertiary care center of Pakistan.World journal of virology · 2025Article
- Critical care management of acute liver failure.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Oxidative Stress in Liver Pathophysiology and Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Liver failure as the initial presentation in cancer of unknown primary: a case report.BMC infectious diseases · 2023Article
- Commentary on COVID-19-induced liver injury in various age and risk groups.World journal of virology · 2023Review
- Biliary Intraepithelial Neoplasia With Gallbladder Adenoma and Cirrhosis: A Case Report.Cureus · 2022Article
- Human Herpesviruses Increase the Severity of Hepatitis.Biology · 2021Article
- Acute viral hepatitis E complicated with acute pancreatitis in an immunocompetent adult.BMJ case reports · 2021Article
- SARS-CoV-2 related liver impairment - perception may not be the reality.Journal of hepatology · 2020Article
- Review
- Intensive Care Management of Acute Liver Failure: Considerations While Awaiting Liver Transplantation.Journal of clinical and translational hepatology · 2019Review
- Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure.Cell death & disease · 2019Article
- Epstein-Barr virus infection is associated with a higher Child-Pugh score and may predict poor prognoses for patients with liver cirrhosis.BMC gastroenterology · 2019Article
- Human cytomegalovirus and Epstein-Barr virus infections, risk factors, and their influence on the liver function of patients with acute-on-chronic liver failure.BMC infectious diseases · 2018Article
- Differential Diagnosis of Hepatic Necrosis Encountered at Autopsy.Academic forensic pathology · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute viral hepatitis (AVH) is mostly caused by hepatitis E (HEV) and hepatitis A (HAV) viruses in India. This study was undertaken to find out the incidence of various hepatotropic and non-hepatotropic viruses in AVH and acute-on-chronic liver failure (ACLF) patients.
methodsSix-hundred and seventy-three adult patients of AVH and ACLF were screened for acute serological markers of hepatotropic (A, B, C, D, and E) and the non-hepatotropic cytomegalovirus (CMV) and Epstein-Barr virus (EBV).
resultsViral etiology profile in 295 samples with confirmed etiology were HEV in 155 (52.5 %); HAV in 43 (14.5 %); HBV in 35 (11.8 %); HCV in 1 (0.3 %); mixed viral etiology in 30 (10.1 %); and non-hepatotropic viruses, cytomegalovirus, and Epstein-Barr virus in 31 (10.5 %). Two-hundred and six patients (69.8 %) were AVH and 89 (30.1 %) ACLF. HEV was the commonest cause of infection in both the groups AVH (n = 95, 46.1 %) and ACLF (n = 60, 67.4 %). Twenty-nine (9.8 %) patients died on follow up; mortality was higher in ACLF (25/89, 28 %) than AVH group (4/206, 1.94 %; p < 0.001). The mortality was higher when HEV was the cause of acute event (20/29, 68.9 %). In AVH, mixed infection was more common as compared to ACLF (27 vs. 3, p < 0.001). Non-hepatotropic viruses contributed significantly higher infections in AVH as compared to ACLF (29 vs. 2, p = 0.002) patients.
conclusionsHEV was an important cause of symptomatic hepatitis in both AVH and ACLF patients. Non-hepatotropic viruses like CMV and EBV were identified in a significant number of patients with AVH and much less frequently in ACLF.
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