ArticleGenes & development2015
Alternate wiring of a KNOXI genetic network underlies differences in leaf development of A. thaliana and C. hirsuta.
Article in Genes & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Overview of molecular mechanisms of plant leaf development: a systematic review.Frontiers in plant science · 2023Pooled it
- Developmental rewiring of the NGAL/CUC/KLU network associated with pleiotropic roles of NGAL genes.The Plant journal : for cell and molecular biology · 2025Article
- CUC/auxin patterning of decanalised petal number inQuantitative plant biology · 2025Article
- A deep learning-based toolkit for 3D nuclei segmentation and quantitative analysis in cellular and tissue context.Development (Cambridge, England) · 2024Article
- Leaf form diversity and evolution: a never-ending story in plant biology.Journal of plant research · 2024Review
- A CUC1/auxin genetic module links cell polarity to patterned tissue growth and leaf shape diversity in crucifer plants.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Shaping leaves through TALE homeodomain transcription factors.Journal of experimental botany · 2024Review
- GRAS transcription factor PINNATE-LIKE PENTAFOLIATA2 controls compound leaf morphogenesis in Medicago truncatula.The Plant cell · 2024Article
- Control of compound leaf patterning by MULTI-PINNATE LEAF1 (MPL1) in chickpea.Nature communications · 2023Article
- SHOOT MERISTEMLESS participates in the heterophylly of Hygrophila difformis (Acanthaceae).Plant physiology · 2022Article
- Developmental Analysis of Compound Leaf Development inFrontiers in plant science · 2022Article
- GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton.Plant biotechnology journal · 2021Article
- The Genetic Control of the Compound Leaf Patterning inFrontiers in plant science · 2021Review
- Integration of Core Mechanisms Underlying Plant Aerial Architecture.Frontiers in plant science · 2021Review
- Upregulation of aProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Plant science's next top models.Annals of botany · 2020Review
- CRISPR/Cas9-Mediated Mutagenesis ofPlants (Basel, Switzerland) · 2020Article
- Transcriptional Landscapes of Divergent Sporophyte Development in Two Mosses,Frontiers in plant science · 2020Article
- Patterning a Leaf by Establishing Polarities.Frontiers in plant science · 2020Review
- SOBIR1/EVR prevents precocious initiation of fiber differentiation during wood development through a mechanism involving BP and ERECTA.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
Abstract
Two interrelated problems in biology are understanding the regulatory logic and predictability of morphological evolution. Here, we studied these problems by comparing Arabidopsis thaliana, which has simple leaves, and its relative, Cardamine hirsuta, which has dissected leaves comprising leaflets. By transferring genes between the two species, we provide evidence for an inverse relationship between the pleiotropy of SHOOTMERISTEMLESS (STM) and BREVIPEDICELLUS (BP) homeobox genes and their ability to modify leaf form. We further show that cis-regulatory divergence of BP results in two alternative configurations of the genetic networks controlling leaf development. In C. hirsuta, ChBP is repressed by the microRNA164A (MIR164A)/ChCUP-SHAPED COTYLEDON (ChCUC) module and ChASYMMETRIC LEAVES1 (ChAS1), thus creating cross-talk between MIR164A/CUC and AS1 that does not occur in A. thaliana. These different genetic architectures lead to divergent interactions of network components and growth regulation in each species. We suggest that certain regulatory genes with low pleiotropy are predisposed to readily integrate into or disengage from conserved genetic networks influencing organ geometry, thus rapidly altering their properties and contributing to morphological divergence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.