ArticlePloS one2015
Preeclampsia and Retinopathy of Prematurity in Very-Low-Birth-Weight Infants: A Population-Based Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 6 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Effect of red blood cell transfusion on the development of retinopathy of prematurity: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Pooled it
- Association between sepsis and retinopathy of prematurity: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Pregnancy-induced hypertension and neonatal outcomes: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2018Pooled it
- Association of maternal hypertensive disorders with retinopathy of prematurity: A systematic review and meta-analysis.PloS one · 2017Pooled it
- Association of Gestational Hypertensive Disorders with Retinopathy of prematurity: A Systematic Review and Meta-analysis.Scientific reports · 2016Pooled it
- Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Clinical Characteristics and Predictive Features of Neonates With Treatment-Needed Retinopathy of Prematurity: A Retrospective Cohort Study.Health science reports · 2025Article
- Retinopathy of prematurity protection conferred by uteroplacental insufficiency through erythropoietin signaling in an experimental Murine Model.Pediatric research · 2023Article
- Downregulation of TCL6 protected human trophoblast cells from LPS-induced inflammation and ferroptosis.Functional & integrative genomics · 2023Article
- Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis.Frontiers in pediatrics · 2023Article
- Neonatal outcomes of twins <29 weeks gestation of mothers with hypertensive disorders of pregnancy.Pediatric research · 2022Article
- Incidence and Characteristics of Retinopathy of Prematurity Patients With Late Gestational Age and Large Birth Weight in South China.Frontiers in medicine · 2022Article
- Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions.Exploration of medicine · 2020Article
- Outcomes of singleton small for gestational age preterm infants exposed to maternal hypertension: a retrospective cohort study.Pediatric research · 2019Article
- Role of cytokines and treatment algorithms in retinopathy of prematurity.Current opinion in ophthalmology · 2017Review
- Pre-eclampsia and the risk of retinopathy of prematurity in preterm infants with birth weight <1500 g and/or <31 weeks' gestation.BMJ open ophthalmology · 2017Article
- Retinopathy of prematurity: a review of risk factors and their clinical significance.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia and retinopathy of prematurity (ROP) are associated with impaired angiogenesis. Previous studies on the relationship between preeclampsia and ROP have produced conflicting results. The goal of this study was to evaluate the association between maternal preeclampsia and ROP using a large population-based cohort of very-low-birth-weight (VLBW) infants from 21 neonatal departments registered in the database of the Premature Baby Foundation of Taiwan. Multivariable logistic regression analysis was used to estimate the adjusted odds ratios (OR) and 95% confidence intervals (CI) for preeclampsia with reference to ROP and severe ROP. A total of 5,718 VLBW infants (844 cases with maternal preeclampsia) were included for analysis. The overall incidences of mild and severe ROP were 36.0% and 12.2%, respectively. Univariable analysis showed lower GA and lower birth weight, vaginal delivery, non-SGA, RDS, PDA, sepsis, transfusion, and absence of maternal preeclampsia to be associated with mild and severe ROP development. However, OR (95% CI) adjusted for the variables that were significant according to univariable analysis showed the risks of developing any-stage ROP and severe ROP for maternal preeclampsia to be 1.00 (0.84-1.20) and 0.89 (0.63-1.25), respectively. The results remained unchanged in stratified analyses according to SGA status. Our data showed that maternal preeclampsia was not associated with the subsequent development of any stage or severe ROP in VLBW infants.
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