ArticleImmunity2015
Not-So-Negative Selection.
Article in Immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Central T cell tolerance from sparse peptide sampling.Science advances · 2026Article
- Integration of kinetic data into affinity-based models for improved T cell specificity prediction.Biophysical journal · 2024Article
- The partitioning of TCR repertoires by thymic selection.The Journal of experimental medicine · 2024Review
- A robust deep learning workflow to predict CD8 + T-cell epitopes.Genome medicine · 2023Article
- Dynamics and specificities of T cells in cancer immunotherapy.Nature reviews. Cancer · 2023Review
- Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis.Nature communications · 2023Article
- Quantitative approaches for decoding the specificity of the human T cell repertoire.Frontiers in immunology · 2023Review
- Determinants of tumor immune evasion: the role of T cell exposed motif frequency and mutant amino acid exposure.Frontiers in immunology · 2023Article
- CD8Diabetes · 2021Article
- Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge.NPJ breast cancer · 2021Review
- Rapid Assessment of T-Cell Receptor Specificity of the Immune Repertoire.Nature computational science · 2021Article
- Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes.Frontiers in immunology · 2021Article
- Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors.Cancer cell · 2020Review
- Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?Diabetologia · 2020Review
- Article
- Sustained Coevolution in a Stochastic Model of Cancer-Immune Interaction.Cancer research · 2020Article
- Islet-reactive CD8Science immunology · 2018Article
- Relationship between CD4 Regulatory T Cells and Anergy In Vivo.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells.Cell reports · 2017Article
- The Thymus/Neocortex Hypothesis of the Brain: A Cell Basis for Recognition and Instruction of Self.Frontiers in cellular neuroscience · 2017Article
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
Abstract
It once seemed clear that negative selection of self-specific T cells in the thymus was the major mechanism of central tolerance. But recent studies, including Legoux et al. (2015) in this issue of Immunity, show that this is not always the case.
Indexed as
Identifiers
26588773What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.