ArticleJournal of cellular physiology2016
Stretching Impacts Inflammation Resolution in Connective Tissue.
Article in Journal of cellular physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04444102 (The Acute Impact of Yoga-based Stretching on Inflammation and Its Resolution), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Acute Impact of Yoga-based Stretching on Inflammation and Its Resolution: a Pilot Study
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between thoracolumbar fascia injury and residual back pain following percutaneous vertebral augmentation: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- A systematic review of in vivo stretching regimens on inflammation and its relevance to translational yoga research.PloS one · 2022Pooled it
- Fu's Subcutaneous Needling Combined with Kinematic Acupuncture versus Electroacupuncture in the Treatment of Cervical Spondylotic Radiculopathy: A Randomized Controlled Trial.Journal of pain research · 2025Trial
- Comparison of Joint Mobilization and Movement Pattern Training for Patients With Hip-Related Groin Pain: A Pilot Randomized Clinical Trial.Physical therapy · 2023Trial
- Static Stretching as a Multilevel Mechanobiological Process: An Integrative Narrative Review and Proposed Framework from Mechanical Loading to Biological Adaptation.Journal of functional morphology and kinesiology · 2026Review
- Fibrosis versus plasticity: a tensegrity-based framework for acupuncture as an exploratory modulator of tissue recovery.Frontiers in physiology · 2026Article
- A synergistic multimodality treatment approach to address the key drivers of wound chronicity.Journal of vascular surgery. Venous and lymphatic disorders · 2026Review
- Technologies to investigate the mechanisms of force-based manipulations: a narrative methods review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Article
- Resolvin D2 Reduces UVB Skin Pathology by Targeting Cytokines, Oxidative Stress, and NF-κB Activation.Antioxidants (Basel, Switzerland) · 2025Article
- The Science of Tai Chi andJournal of integrative and complementary medicine · 2025Review
- Investigation of the efficiency of pulsed electromagnetic field treatment and stretching exercise in experimental skeletal muscle injury model.BMC musculoskeletal disorders · 2025Article
- Fu's subcutaneous needling approach versus electroacupuncture for knee osteoarthritis: protocol for comparative effectiveness and safety randomized controlled trial.Frontiers in medicine · 2025Article
- Botulinum toxin combined with static progressive stretching improves fibrous stiffness of knee joint in rats through TGF-β1/Smad pathway.Biomolecules & biomedicine · 2024Article
- Integrated manual therapies: IASP taskforce viewpoint.Pain reports · 2024Article
- Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment.APL bioengineering · 2024Review
- Effect of stretching on inflammation in a subcutaneous carrageenan mouse model analyzed at single-cell resolution.Journal of cellular physiology · 2023Article
- Response to Mechanical Properties and Physiological Challenges of Fascia: Diagnosis and Rehabilitative Therapeutic Intervention for Myofascial System Disorders.Bioengineering (Basel, Switzerland) · 2023Review
- Possible mechanism of static progressive stretching combined with extracorporeal shock wave therapy in reducing knee joint contracture in rats based on MAPK/ERK pathway.Biomolecules & biomedicine · 2023Article
- Mechanisms Underlying Anti-Inflammatory and Anti-Cancer Properties of Stretching-A Review.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Acute inflammation is accompanied from its outset by the release of specialized pro-resolving mediators (SPMs), including resolvins, that orchestrate the resolution of local inflammation. We showed earlier that, in rats with subcutaneous inflammation of the back induced by carrageenan, stretching for 10 min twice daily reduced inflammation and improved pain, 2 weeks after carrageenan injection. In this study, we hypothesized that stretching of connective tissue activates local pro-resolving mechanisms within the tissue in the acute phase of inflammation. In rats injected with carrageenan and randomized to stretch versus no stretch for 48 h, stretching reduced inflammatory lesion thickness and neutrophil count, and increased resolvin (RvD1) concentrations within lesions. Furthermore, subcutaneous resolvin injection mimicked the effect of stretching. In ex vivo experiments, stretching of connective tissue reduced the migration of neutrophils and increased tissue RvD1 concentration. These results demonstrate a direct mechanical impact of stretching on inflammation-regulation mechanisms within connective tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.