Evidence map›Paper›PMID 26587987›Full record

ArticlePloS one2015

Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons.

Erling Mellerup, Ole A Andreassen, Bente Bennike, Henrik Dam, Srdjan Djurovic, Thomas Hansen, Martin Balslev Jorgensen, Lars Vedel Kessing, Pernille Koefoed, Ingrid Melle and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Combinations of Genetic Variants Occurring Exclusively in Patients.Computational and structural biotechnology journal · 2017
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Erling MellerupLaboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
Ole A AndreassenDepartment of Psychiatry, Oslo University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166. 0407 Oslo, Norway.
Bente BennikeLaboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
Henrik DamPsychiatric Centre Copenhagen, Department O, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
Srdjan DjurovicDepartment of Medical Genetics, Oslo University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166. 0407 Oslo, Norway.
Thomas HansenDepartment of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, Boserupvej 2, DK-4000 Roskilde, Denmark.
Martin Balslev JorgensenPsychiatric Centre Copenhagen, Department O, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
Lars Vedel KessingPsychiatric Centre Copenhagen, Department O, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
Pernille KoefoedLaboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 9 O-6102, DK-2100 Copenhagen, Denmark.
Ingrid MelleDepartment of Psychiatry, Oslo University Hospital and Institute of Psychiatry, University of Oslo, Kirkeveien 166. 0407 Oslo, Norway.
Ole MorsCentre for Psyciatric Research, Aarhus University Hospital, Skovagervej 2, DK-8240 Risskov, Denmark.
Thomas WergeDepartment of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, Boserupvej 2, DK-4000 Roskilde, Denmark.
Gert Lykke MoellerGenokey ApS, ScionDTU, Technical University Denmark, Agern Allé 3, DK-2970 Hoersholm, Denmark.
Copenhagen University Hospital · DKRigshospitalet · DKUniversity of Oslo · NOUniversity of Copenhagen · DKAarhus University Hospital · DKTechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideBipolar DisorderCase-Control StudiesCluster AnalysisDenmarkGenotypeHumansModels, GeneticModels, StatisticalNorwayRisk Factors

Identifiers

PMID26587987
PMCPMC4654514
OpenAlexW2180730091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.