ArticleThe Journal of comparative neurology2016
Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina.
Article in The Journal of comparative neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 66 citations in OpenAlex.
- Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus.Investigative ophthalmology & visual science · 2026Article
- Optogenetic Isolation of the Amacrine Cell-OFF Bipolar Cell Synapse Shows Selective D1R Control of Glycinergic Transmission.bioRxiv : the preprint server for biology · 2026Article
- Validation of eye occluding device developed from bottle caps for dopamine studies in rabbits: A pilot study.Open veterinary journal · 2026Article
- Differences in the Effect of Dopamine on the Phototransduction Between Lampreys and Jawed Vertebrates.International journal of molecular sciences · 2026Article
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- A study on electroretinography as a biomarker for seasonal vulnerability in depression.Translational psychiatry · 2025Article
- Activation of Dopamine D1 Receptors at the Axon Initial Segment-Like Process of Retinal AII Amacrine Cells Modulates Action Potential Firing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions.Frontiers in cellular neuroscience · 2025Article
- Impaired dopamine signaling in early diabetic retina: Insights from D1R and D4R agonist effects on whole retina responses.Experimental eye research · 2024Article
- Retinal bipolar cells borrow excitability from electrically coupled inhibitory interneurons to amplify excitatory synaptic transmission.bioRxiv : the preprint server for biology · 2024Article
- A presynaptic source drives differing levels of surround suppression in two mouse retinal ganglion cell types.Nature communications · 2024Article
- Update on central factors in myopia development beyond intraocular mechanisms.Frontiers in neurology · 2024Review
- The Role of Retinal Dopamine D1 Receptors in Ocular Growth and Myopia Development in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Visual Dysfunction in Diabetes.Annual review of vision science · 2023Review
- Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development.BMC biology · 2023Article
- Off Starburst Amacrine Cells in the Retina Trigger Looming-Evoked Fear Responses in Mice.eNeuro · 2023Article
- Starburst amacrine cells form gap junctions in the early postnatal stage of the mouse retina.Frontiers in cellular neuroscience · 2023Article
- Diurnal changes in the efficiency of information transmission at a sensory synapse.Nature communications · 2022Article
- Impaired Light Adaptation of ON-Sustained Ganglion Cells in Early Diabetes Is Attributable to Diminished Response to Dopamine D4 Receptor Activation.Investigative ophthalmology & visual science · 2022Article
- Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells.Journal of neurophysiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In the retina, dopamine is a key molecule for daytime vision. Dopamine is released by retinal dopaminergic amacrine cells and transmits signaling either by conventional synaptic or by volume transmission. By means of volume transmission, dopamine modulates all layers of retinal neurons; however, it is not well understood how dopamine modulates visual signaling pathways in bipolar cells. Here we analyzed Drd1a-tdTomato BAC transgenic mice and found that the dopamine D1 receptor (D1R) is expressed in retinal bipolar cells in a type-dependent manner. Strong tdTomato fluorescence was detected in the inner nuclear layer and localized to type 1, 3b, and 4 OFF bipolar cells and type 5-2, XBC, 6, and 7 ON bipolar cells. In contrast, type 2, 3a, 5-1, 9, and rod bipolar cells did not express Drd1a-tdTomato. Other interneurons were also found to express tdTomato including horizontal cells and a subset (25%) of AII amacrine cells. Diverse visual processing pathways, such as color or motion-coded pathways, are thought to be initiated in retinal bipolar cells. Our results indicate that dopamine sculpts bipolar cell performance in a type-dependent manner to facilitate daytime vision. J. Comp. Neurol. 524:2059-2079, 2016. © 2015 Wiley Periodicals, Inc.
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