ArticleBioMed research international2015
A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Structural determinants of re-entrant drivers in atrial fibrillation: insights from digital twins derived from 3D micrometre-resolution imaging of human heart.The Journal of physiology · 2026Article
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- The role of the Cx43/Cx45 gap junction voltage gating on wave propagation and arrhythmogenic activity in cardiac tissue.Scientific reports · 2023Article
- Restitution Slope Affects the Outcome of Dominant Frequency Ablation in Persistent Atrial Fibrillation: CUVIA-AF2Frontiers in cardiovascular medicine · 2022Article
- Article
- The role of personalized atrial modeling in understanding atrial fibrillation mechanisms and improving treatment.International journal of cardiology · 2019Review
- Understanding AF Mechanisms Through Computational Modelling and Simulations.Arrhythmia & electrophysiology review · 2019Review
- Chaotic tip trajectories of a single spiral wave in the presence of heterogeneities.Physical review. E · 2019Article
- Variability in pulmonary vein electrophysiology and fibrosis determines arrhythmia susceptibility and dynamics.PLoS computational biology · 2018Article
- Atrial Rotor Dynamics Under Complex Fractional Order Diffusion.Frontiers in physiology · 2018Article
- Computational assessment of the functional role of sinoatrial node exit pathways in the human heart.PloS one · 2017Article
- BeatBox-HPC simulation environment for biophysically and anatomically realistic cardiac electrophysiology.PloS one · 2017Article
- Optimization of catheter ablation of atrial fibrillation: insights gained from clinically-derived computer models.International journal of molecular sciences · 2015Review
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Authors and funding
5 authors.
Funding
Abstract
The interaction of spiral waves of excitation with atrial anatomy remains unclear. This simulation study isolates the role of atrial anatomical structures on spiral wave spontaneous drift in the human atrium. We implemented realistic and idealised 3D human atria models to investigate the functional impact of anatomical structures on the long-term (∼40 s) behaviour of spiral waves. The drift of a spiral wave was quantified by tracing its tip trajectory, which was correlated to atrial anatomical features. The interaction of spiral waves with the following idealised geometries was investigated: (a) a wedge-like structure with a continuously varying atrial wall thickness; (b) a ridge-like structure with a sudden change in atrial wall thickness; (c) multiple bridge-like structures consisting of a bridge connected to the atrial wall. Spiral waves drifted from thicker to thinner regions and along ridge-like structures. Breakthrough patterns caused by pectinate muscles (PM) bridges were also observed, albeit infrequently. Apparent anchoring close to PM-atrial wall junctions was observed. These observations were similar in both the realistic and the idealised models. We conclude that spatially altering atrial wall thickness is a significant cause of drift of spiral waves. PM bridges cause breakthrough patterns and induce transient anchoring of spiral waves.
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