ArticleBioMed research international2015
ECG-Based Detection of Early Myocardial Ischemia in a Computational Model: Impact of Additional Electrodes, Optimal Placement, and a New Feature for ST Deviation.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Long-term, ambulatory 12-lead ECG from a single non-standard lead using perceptual reconstruction.medRxiv : the preprint server for health sciences · 2025Article
- Early Detection of Inferolateral Ischemia Using a Smartphone-Based ECG Device: A Case of Triple-Vessel Disease Confirmed by Coronary Angiography.Acta medica academica · 2025Article
- Computational modelling of biological systems now and then: revisiting tools and visions from the beginning of the century.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability.Interface focus · 2021Article
- Noninvasive Imaging of Epicardial and Endocardial Potentials With Low Rank and Sparsity Constraints.IEEE transactions on bio-medical engineering · 2019Article
- A modeling and machine learning approach to ECG feature engineering for the detection of ischemia using pseudo-ECG.PloS one · 2019Article
- Cardiac ischemia-insights from computational models.Herzschrittmachertherapie & Elektrophysiologie · 2018Review
- Article
- Reducing Error in ECG Forward Simulations With Improved Source Sampling.Frontiers in physiology · 2018Article
- ECG imaging of ventricular tachycardia: evaluation against simultaneous non-contact mapping and CMR-derived grey zone.Medical & biological engineering & computing · 2017Article
- Comparison of Baseline Wander Removal Techniques considering the Preservation of ST Changes in the Ischemic ECG: A Simulation Study.Computational and mathematical methods in medicine · 2017Article
- Intramyocardial Injection of siRNAs Can Efficiently Establish Myocardial Tissue-Specific Renalase Knockdown Mouse Model.BioMed research international · 2016Article
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Authors and funding
7 authors.
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Abstract
In case of chest pain, immediate diagnosis of myocardial ischemia is required to respond with an appropriate treatment. The diagnostic capability of the electrocardiogram (ECG), however, is strongly limited for ischemic events that do not lead to ST elevation. This computational study investigates the potential of different electrode setups in detecting early ischemia at 10 minutes after onset: standard 3-channel and 12-lead ECG as well as body surface potential maps (BSPMs). Further, it was assessed if an additional ECG electrode with optimized position or the right-sided Wilson leads can improve sensitivity of the standard 12-lead ECG. To this end, a simulation study was performed for 765 different locations and sizes of ischemia in the left ventricle. Improvements by adding a single, subject specifically optimized electrode were similar to those of the BSPM: 2-11% increased detection rate depending on the desired specificity. Adding right-sided Wilson leads had negligible effect. Absence of ST deviation could not be related to specific locations of the ischemic region or its transmurality. As alternative to the ST time integral as a feature of ST deviation, the K point deviation was introduced: the baseline deviation at the minimum of the ST-segment envelope signal, which increased 12-lead detection rate by 7% for a reasonable threshold.
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