ArticleIranian journal of public health2015
Molecular Diversity of Candida albicans Isolated from Immunocompromised Patients, Based on MLST Method.
Article in Iranian journal of public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Characterization ofCurrent medical mycology · 2021Article
- In vitro activity of four triazole antifungal drugs against clinically common and uncommon yeast species.Current medical mycology · 2019Article
- Quantification of CDR1 Gene Expression in Fluconazole Resistant Candida Glabrata Strains Using Real-time PCR.Iranian journal of public health · 2017Article
- Caspofungin-Non-SusceptibleIranian journal of public health · 2017Article
- Article
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4 authors.
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Abstract
backgroundAs regards multilocus sequence typing (MLST) method directly analyze the polymorphism within DNA sequences; we performed the first nationwide study on the genotypic relationships of Candida albicans strains obtained from oropharynx and bronchoalveolar lavage (BAL) samples from immunocompromised patients.
methodsFourteen epidemiologically unrelated clinical strains of C. albicans were obtained from three hospitals in Mazandaran Province, Iran (2006 to 2012) from seven patients with pulmonary infections and the rest with oropharyngeal samples of immunocompromised patients. Seven loci of housekeeping genes were sequenced for all fourteen isolates.
resultsMLST was applied to a subset of 14 unrelated isolates. Seventy-one (2.5%) nucleotide sites were found to be variable. Accordingly, 60 different alleles were identified in seven loci among the isolates, among which two new alleles were obtained. Furthermore, 12 independent diploid sequence types (DSTs) including five novel DSTs were identified. The fourteen unrelated isolates were placed in 10 clonal clusters (CC) while two isolates were singletons, by eBURST analysis. Most of the isolates belonged to CC461 of eBURST analysis from the clade 11 and two isolates assigned to CC172 from the clade 15.
conclusionPathogen distribution and relatedness for determining the epidemiology of nosocomial infections is highly recommended for pathogen control methods.
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