Evidence map›Paper›PMID 26587403›Full record

ArticleAnesthesiology and pain medicine2015

Influence of Ketamine on Early Postoperative Cognitive Function After Orthopedic Surgery in Elderly Patients.

Ki Hwa Lee, Ji Yeon Kim, Jeong Won Kim, Jang Su Park, Kyu Won Lee, Sang Yoon Jeon

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
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Article in Anesthesiology and pain medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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  15. Effect of memantine on post-operative cognitive dysfunction after cardiac surgeries: a randomized clinical trial.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ki Hwa LeeDepartment of Anesthesia and Pain Medicine, Haeundae Paik Hospital, Inje University, Busan, South Korea.
Ji Yeon KimDepartment of Anesthesia and Pain Medicine, Ilsan Paik Hospital, Inje University, Goyang, South Korea.
Jeong Won KimDepartment of Anesthesia and Pain Medicine, Ilsan Paik Hospital, Inje University, Goyang, South Korea.
Jang Su ParkDepartment of Anesthesia and Pain Medicine, Ilsan Paik Hospital, Inje University, Goyang, South Korea.
Kyu Won LeeDepartment of Anesthesia and Pain Medicine, Haeundae Paik Hospital, Inje University, Busan, South Korea.
Sang Yoon JeonDepartment of Anesthesia and Pain Medicine, Halla Hospital, Jeju, South Korea.
Inje University Ilsan Paik Hospital · KRInje University Haeundae Paik Hospital · KRCheju Halla General Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative cognitive dysfunction (POCD) is a serious and frequent complication after surgery, especially in elderly patients. Ketamine is an N-methyl D-aspartic acid receptor antagonist with demonstrated neuroprotective effects. An intravenous bolus of a sub-anesthetic dose (0.5 mg/kg) of ketamine can reduce postoperative delirium (POD) and POCD after cardiac surgery. But, the influence of ketamine on early POCD after non-cardiac surgery is unclear.

objectivesThe current study aimed to evaluate the influence of ketamine on early postoperative cognitive function after orthopedic surgery in elderly patients. PATIENTS AND

methodsFifty six elderly patients (> 60-years-old), scheduled for elective orthopedic surgery during general anesthesia (duration of anesthesia > two hours) were enrolled. Patients received intravenous bolus, a total of 3 mL mixed with 0.9% normal saline and 0.5 mg/kg ketamine (K group) or 3 mL of 0.9% normal saline (N group). Three neurocognitive function tests (mini-mental status examination, trail-making test, digit substitution test), and c-reactive protein (CRP) concentration were determined before surgery and on postoperative day one (POD 1) and postoperative day six (POD 6).

resultsThe two groups had similar demographic characteristics except for the gender. Surgical and anesthetic data were not significantly different. A statistically significant difference was observed in comparison of trail-making test score. Trail-making test score increased more in the N group (52.5 points) than the K group (13 points) at POD 1 (P = 0.047) compared with baseline scores. There were no significant differences in the mini-mental status examination, digit substitution test and CRP concentration at POD 1 and POD 6 between the two groups. POCD (the two Z-scores in more than two tests or the combined Z-score was 1.96 or more) was present in one patient (4%) in the K group at POD 6 (P = 0.98).

conclusionsThe incidence of POCD was not significantly influenced by a bolus dose of ketamine (0.5 mg/kg) after orthopedic surgery in elderly patients. There were no negative effects of ketamine on early POCD.

Indexed as

Cognitive DisordersDesfluraneKetamine

Identifiers

PMID26587403
PMCPMC4644306
OpenAlexW2190527419

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.