Evidence map›Paper›PMID 26587320›Full record

ArticleOncoimmunology2015

Absence of myeloperoxidase and CD8 positive cells in colorectal cancer infiltrates identifies patients with severe prognosis.

Silvio Däster, Serenella Eppenberger-Castori, Christian Hirt, Savas D Soysal, Tarik Delko, Christian A Nebiker, Benjamin Weixler, Francesca Amicarella, Giandomenica Iezzi, Valeria Governa and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Tumour-infiltrating CD8British journal of cancer · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Silvio DästerDepartment of Surgery; University Hospital Basel ; Basel, Switzerland ; Institute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Serenella Eppenberger-CastoriInstitute of Pathology; University Hospital Basel ; Basel, Switzerland.
Christian HirtDepartment of Surgery; University Hospital Basel ; Basel, Switzerland ; Institute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Savas D SoysalDepartment of Surgery; University Hospital Basel ; Basel, Switzerland ; Institute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Tarik DelkoDepartment of Surgery; University Hospital Basel ; Basel, Switzerland.
Christian A NebikerDepartment of Surgery; University Hospital Basel ; Basel, Switzerland ; Institute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Benjamin WeixlerDepartment of Surgery; University Hospital Basel ; Basel, Switzerland.
Francesca AmicarellaInstitute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Giandomenica IezziInstitute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Valeria GovernaInstitute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Elisabetta PadovanInstitute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Valentina MeleInstitute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Giuseppe SconocchiaInstitute of Translational Pharmacology, Department of Biomedicine; National Research Council , Rome, Italy.
Michael HebererInstitute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Luigi TerraccianoInstitute of Pathology; University Hospital Basel ; Basel, Switzerland.
Christoph KettelhackDepartment of Surgery; University Hospital Basel ; Basel, Switzerland.
Daniel OertliDepartment of Surgery; University Hospital Basel ; Basel, Switzerland.
Giulio C SpagnoliInstitute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.
Urs von HolzenDepartment of Surgery; University Hospital Basel ; Basel, Switzerland ; Indiana University School of Medicine South Bend, Indiana University Health Goshen Center for Cancer Care , Goshen, IN, USA.
Luigi TornilloInstitute of Pathology; University Hospital Basel ; Basel, Switzerland.
Raoul A DroeserDepartment of Surgery; University Hospital Basel ; Basel, Switzerland ; Institute of Surgical Research and Hospital Management, Department of Biomedicine; University of Basel , Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) infiltration by cells expressing myeloperoxidase (MPO) or CD8 positive T lymphocytes has been shown to be independently associated with favorable prognosis. We explored the relationship occurring between CD8+ and MPO+ cell CRC infiltration, its impact on clinical-pathological features and its prognostic significance in a tissue microarray (TMA) including 1,162 CRC. We observed that CRC showing high MPO+ cell infiltration are characterized by a prognosis as favorable as that of cancers with high CD8+ T cell infiltration. However, MPO+ and CD8+ CRC infiltrating cells did not synergize in determining a more favorable outcome, as compared with cancers showing MPO

Indexed as

CD8+human colorectal cancermyeloperoxidaseprognostic markerstissue microarray

Identifiers

PMID26587320
PMCPMC4635694

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.