ArticleRoyal Society open science2015
The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance.
Article in Royal Society open science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- How optimal control of cellular cost shapes population-level tumor growth dynamics.bioRxiv : the preprint server for biology · 2026Article
- Article
- Targeting Precision in Cancer Immunotherapy: Naturally-Occurring Antigen-Specific TCR Discovery with Single-Cell Sequencing.Cancers · 2024Article
- Modified Dendritic cell-based T-cell expansion protocol and single-cell multi-omics allow for the selection of the most expanded andFrontiers in immunology · 2024Article
- The coordination of anti-phage immunity mechanisms in bacterial cells.Nature communications · 2022Article
- Killing the competition: a theoretical framework for liver-stage malaria.Open biology · 2022Article
- Predator-Prey in Tumor-Immune Interactions: A Wrong Model or Just an Incomplete One?Frontiers in immunology · 2021Article
- Functional categories of immune inhibitory receptors.Nature reviews. Immunology · 2020Review
- Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants.Immunity · 2020Article
- Sustained Coevolution in a Stochastic Model of Cancer-Immune Interaction.Cancer research · 2020Article
- Immunological Paradigms, Mechanisms, and Models: Conceptual Understanding Is a Prerequisite to Effective Modeling.Frontiers in immunology · 2019Review
- Stochastic modeling of tumor progression and immune evasion.Journal of theoretical biology · 2018Article
- Modeling the effect of boost timing in murine irradiated sporozoite prime-boost vaccines.PloS one · 2018Article
- Population mechanics: A mathematical framework to study T cell homeostasis.Scientific reports · 2017Article
- A Dynamic Model of Immune Responses to Antigen Presentation Predicts Different Regions of Tumor or Pathogen Elimination.Cell systems · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptive immune responses depend on the capacity of T cells to target specific antigens. As similar antigens can be expressed by pathogens and host cells, the question naturally arises of how can T cells discriminate friends from foes. In this work, we suggest that T cells tolerate cells whose proliferation rates remain below a permitted threshold. Our proposal relies on well-established facts about T-cell dynamics during acute infections: T-cell populations are elastic (they expand and contract) and they display inertia (contraction is delayed relative to antigen removal). By modelling inertia and elasticity, we show that tolerance to slow-growing populations can emerge as a population-scale feature of T cells. This result suggests a theoretical framework to understand immune tolerance that goes beyond the self versus non-self dichotomy. It also accounts for currently unexplained observations, such as the paradoxical tolerance to slow-growing pathogens or the presence of self-reactive T cells in the organism.
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