ArticleJournal of the National Cancer Institute2016
The Role of Prolactin in Bone Metastasis and Breast Cancer Cell-Mediated Osteoclast Differentiation.
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Article in Journal of the National Cancer Institute, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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34citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Genome-wide Association Study Identified Chromosome 8 Locus Associated with Medication-Related Osteonecrosis of the Jaw.Clinical pharmacology and therapeutics · 2021Pooled it
- Review
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- Regulatory effects of lncRNA PVT1 on transcriptome in human breast cancer MDA-MB-231 cell line determined by in silico analyses.Chromosoma · 2025Article
- The Breast to Bone (B2B) Cohort Study to Prevent, Detect and Improve Treatment of Metastatic Disease: Baseline Assessment, Description and Progress.International journal of environmental research and public health · 2025Article
- Prolactin and DNA damage trigger an anti-breast cancer cell immune response.Frontiers in endocrinology · 2025Article
- Isolated hypoprolactinemia: The rarest of the rare?Reviews in endocrine & metabolic disorders · 2024Review
- Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment.Cancers · 2024Review
- Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions.Cell & bioscience · 2023Review
- Organ-Specificity of Breast Cancer Metastasis.International journal of molecular sciences · 2023Review
- Modulation of JAK-STAT Signaling by LNK: A Forgotten Oncogenic Pathway in Hormone Receptor-Positive Breast Cancer.International journal of molecular sciences · 2023Review
- Circulating biomarkers for diagnosis and therapeutic monitoring in bone metastasis.Journal of bone and mineral metabolism · 2023Review
- PRLR and CACNA2D1 Impact the Prognosis of Breast Cancer by Regulating Tumor Immunity.Journal of personalized medicine · 2022Article
- The Binomial "Inflammation-Epigenetics" in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell Line.International journal of molecular sciences · 2022Article
- Breast Cancer and Prolactin - New Mechanisms and Models.Endocrinology · 2022Review
- Characteristics and survival in bone metastatic breast cancer patients with different hormone receptor status: A population-based cohort study.Frontiers in oncology · 2022Article
- Prolactin receptor signaling: A novel target for cancer treatment - Exploring anti-PRLR signaling strategies.Frontiers in endocrinology · 2022Review
- Prolactin: The Third Hormone in Breast Cancer.Frontiers in endocrinology · 2022Review
- The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level.Journal of clinical medicine · 2021Article
- Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment.Journal of cellular and molecular medicine · 2021Review
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Authors and funding
18 authors at 1 institution in 3 countries.
Ashley SutherlandAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Amanda ForsythAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Yingying CongAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Laurel GrantAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Tzu-Hua JuanAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Jae K LeeAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Alexander KlimowiczAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Stephanie K PetrilloAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Jinghui HuAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Angela ChanAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Florence BoutillonAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Vincent GoffinAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Cay EganAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Patricia A TangAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Li CaiAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Don MorrisAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Anthony MaglioccoAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Carrie S ShemankoAffiliations of authors: University of Calgary, Department of Biological Sciences and Arnie Charbonneau Cancer Institute , Calgary , Canada (AS, AF, YC, LG, CSS); H. Lee Moffitt Cancer Center & Research Institute, Department of Biostatistics and Bioinformatics , Tampa, FL (THJ, JKL); Tom Baker Cancer Centre, Translational Labs , Calgary , Canada (AK, SKP, JH, AC, CE, PAT, DM, AM); Université Paris Descartes, Inserm U1151, Institut Necker Enfants Malades (INEM), Team "Pathophysiology of PRL/GH" , Paris , France (FB, VG); Medical Department of Breast Oncology, The Tumor Hospital of Harbin Medical University , Harbin , China (YC, LC); H. Lee Moffitt Cancer Center & Research Institute, Department of Anatomical Pathology , Tampa, FL (AM).
Ontario Institute for Cancer Research · CA
Funding
Canadian Institutes of Health Research 126447
Abstract
backgroundMetastasis to the bone is a deleterious aspect of breast cancer and is a preferred site that results in bone loss. Hormones such as prolactin (PRL) have not yet been studied for their role in modulating the secondary tumor bone microenvironment.
methodsWe used quantitative immunohistochemistry with 134 samples of human primary breast cancer and 17 matched primary breast cancers and bone metastases. A Cox proportional hazards regression model was fitted to evaluate the associations between high prolactin receptor (PRLR) expression and time to bone metastasis, adjusting for estrogen receptor status, lymph node status, and chemotherapy status. We assessed osteoclast differentiation, osteoclast size, and measured pit formation in dentine slices. Statistical tests were two-sided.
resultsHigh PRLR expression in the primary breast tumor was associated with a shorter time to metastasis that includes bone (PRLRAQUA Max-per 100 unit hazard ratio = 1.04, 95% confidence interval = 1.00 to 1.07, P = .03). We observed the PRLR in rare samples of bone metastases and matched primary breast cancer. PRL treatment of breast cancer cells induced osteoclast differentiation and bone lysis via secreted factors and was abrogated by a PRLR antagonist (delta1-9-G129R-hPRL). We demonstrated that sonic hedgehog is a PRL-regulated cytokine in breast cancer cells and part of the mechanism that induces osteoclast differentiation.
conclusionsOur evidence indicates that PRL-PRLR can escalate the impact of breast cancer on bone metastasis and that the presence of the PRLR in the tumor microenvironment of breast cancer bone metastasis has the potential to modulate the microenvironment to induce lytic osteoclast formation.
Indexed as
Cell DifferentiationSignal TransductionAdultAgedBone NeoplasmsBreast NeoplasmsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHedgehog ProteinsHumansImmunohistochemistryMiddle AgedNeoplastic Cells, CirculatingOdds RatioOsteoclastsHedgehog ProteinsProlactinReceptors, ProlactinSHH protein, human
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