Evidence map›Paper›PMID 26586494›Full record

Trial reportJournal of cancer survivorship : research and practice2016

Randomized controlled pilot trial of mindfulness-based stress reduction for breast and colorectal cancer survivors: effects on cancer-related cognitive impairment.

Shelley A Johns, Diane Von Ah, Linda F Brown, Kathleen Beck-Coon, Tasneem L Talib, Jennifer M Alyea, Patrick O Monahan, Yan Tong, Laura Wilhelm, R Brian Giesler

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cancer survivorship : research and practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06366685 (Development and Initial Application of a Combined Exercise and Psychological Intervention Program for Patients After Esophagectomy), which is not on this map. Cited by 48 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 9 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06366685 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Development and Initial Application of a Combined Exercise and Psychological Intervention Program for Patients After Esophagectomy

TypeinterventionalSponsorMengmeng YuanRan2024 to 2025Enrolled60ConditionsEsophageal Cancer, Exercise Training, Psychotherapy, RehabilitationArmsExercise and Psychological Intervention
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 9 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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  14. The Health Promoting Mindfulness or Qigong Educational Programs for Beneficial Lifestyle Changes of Cancer Survivors.Journal of cancer education : the official journal of the American Association for Cancer Education · 2020
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  17. Recent advances in understanding chemotherapy-induced fatigue in BC patients residing in high-altitude regions: a review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Shelley A JohnsIndiana University School of Medicine, Indianapolis, IN, USA. sheljohn@iu.edu.
Diane Von AhIndiana University School of Nursing, Indianapolis, IN, USA.
Linda F BrownIndiana University School of Medicine, Indianapolis, IN, USA.
Kathleen Beck-CoonIndiana University School of Medicine, Indianapolis, IN, USA.
Tasneem L TalibRegenstrief Institute, Incorporation, 1050 Wishard Blvd-RG5105, Indianapolis, IN, 46202, USA.
Jennifer M AlyeaIndiana University Fairbanks School of Public Health, Indianapolis, IN, USA.
Patrick O MonahanIndiana University School of Medicine, Indianapolis, IN, USA.
Yan TongIndiana University School of Medicine, Indianapolis, IN, USA.
Laura WilhelmWest Virginia University School of Medicine, Charleston, WV, USA.
R Brian GieslerButler University, Indianapolis, IN, USA.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · USButler University · USRegenstrief Institute · USWest Virginia University · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Indiana Clinical and Translational Science Institute (UL1)UL1TR000006 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2012 to 2013
$5.6M
Indiana Clinical and Translational Science Institute-K12 ProgramKL2TR000163 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2012 to 2013
$720k
Research and Training for Behavioral Oncology InterventionsK05CA175048 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI CHAMPION, VICTORIA LEE · 2014 to 2018
$484k
NCATS NIH HHS KL2 TR000163NCATS NIH HHS UL1 TR000006NCATS NIH HHS UL1 TR001108NCI NIH HHS K05 CA175048
6 · The paper itself

Abstract

purposeCancer-related cognitive impairment (CRCI) is a common, fatigue-related symptom that disrupts cancer survivors' quality of life. Few interventions for CRCI exist. As part of a randomized pilot study targeting cancer-related fatigue, the effects of mindfulness-based stress reduction (MBSR) on survivors' cognitive outcomes were investigated.

methodsBreast and colorectal cancer survivors (n = 71) with moderate-to-severe fatigue were randomized to MBSR (n = 35) or a fatigue education and support (ES; n = 36) condition. The Attentional Function Index (AFI) and the Stroop test were used to assess survivors' cognitive function at baseline (T1), after the 8-week intervention period (T2), and 6 months later (T3) using intent-to-treat analysis. Mediation analyses were performed to explore mechanisms of intervention effects on cognitive functioning.

resultsMBSR participants reported significantly greater improvement on the AFI total score compared to ES participants at T2 (d = 0.83, p = 0.001) and T3 (d = 0.55, p = 0.021). MBSR also significantly outperformed ES on most AFI subscales, although both groups improved over time. MBSR produced greater Stroop accuracy rates relative to ES at T2 (r = 0.340, p = 0.005) and T3 (r = 0.280, p = 0.030), with improved accuracy over time only for the MBSR group. There were no significant differences in Stroop reaction time between groups. Improvements in mindfulness mediated the effect of group (e.g., MBSR vs. ES) on AFI total score at T2 and T3.

conclusionsAdditional randomized trials with more comprehensive cognitive measures are warranted to definitively assess the efficacy of MBSR for CRCI. IMPLICATIONS FOR CANCER SURVIVORS: This pilot study has important implications for all cancer survivors as it is the first published trial to show that MBSR offers robust and durable improvements in CRCI.

Indexed as

MindfulnessAdultAgedBreast NeoplasmsCognitive DysfunctionColorectal NeoplasmsFatigueFemaleHumansMaleMiddle AgedPilot ProjectsQuality of LifeStress, PsychologicalSurvivorsTreatment OutcomeAttentionCancerCognitionMBSRMindfulnessOncology

Identifiers

PMID26586494
PMCPMC4864185
OpenAlexW2193610178

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.