ArticleThe Journal of allergy and clinical immunology2016
Changes in IgE sensitization and total IgE levels over 20 years of follow-up.
Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
- Prevalence of food allergies in older adults: A systematic review and meta-analysis.The World Allergy Organization journal · 2026Review
- Risk Factors for COVID-19 mRNA Vaccine-Associated Exacerbations in Patients With Obstructive Airway Diseases: REsearch for Asthma and COPD ExacerbaTION Caused by COVID-19 mRNA Vaccination (REACTION Study).Allergy, asthma & immunology research · 2026Article
- Prevalence and Patterns of Allergen Sensitization in Southern China: A Retrospective Analysis of 18,777 Routine Checkup Participants in Shenzhen.Journal of asthma and allergy · 2026Article
- Evaluation on the clinical findings and allergological factors of local allergic conjunctivitis and non-local allergic conjunctivitis.Scientific reports · 2025Article
- Molecular Signatures of Aeroallergen Sensitization in Pediatric Populations: A Comparative Study Across Spanish Cities.International journal of molecular sciences · 2025Article
- Inflammation and aging-related disease: A transdisciplinary inflammaging framework.GeroScience · 2025Review
- Trends in Allergic Sensitization and Diseases in the Korean General Population Over a 9-Year Period.Clinical and experimental otorhinolaryngology · 2025Article
- Allergy in Young Adults Associates with Elevated Fractional Exhaled Nitric Oxide Levels and IgE-Verified Parental Allergy but Is Confounded by Self-Reported Symptoms.International archives of allergy and immunology · 2024Article
- Factors associated with aeroallergen testing among adults with asthma in a large health system.The journal of allergy and clinical immunology. Global · 2023Article
- Food hypersensitivity: an examination of factors influencing symptoms and temporal changes in the prevalence of sensitization in an adult sample.European journal of clinical nutrition · 2023Article
- Reference values of serum total IgE in Uppsala - comparison over four decades.Upsala journal of medical sciences · 2023Article
- A Proposal to Differentiate ACO, Asthma and COPD in Vietnam.Journal of personalized medicine · 2022Article
- A new way forward? Examining the potential of quantitative analysis of IgE datasets.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- One Year in the Extreme Isolation of Antarctica-Is This Enough to Modulate an "Allergic" Sensitization?Biomedicines · 2022Article
- The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories.The European respiratory journal · 2021Article
- Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach.The European respiratory journal · 2021Article
- Relationship between longitudinal changes in type-2 inflammation, immunoglobulin E sensitization, and clinical outcomes in young asthmatics.Clinical and translational allergy · 2021Article
- Response of upper and lower airway inflammation to bronchial challenge with house dust mite in Chinese asthmatics: a pilot study.Journal of thoracic disease · 2021Article
- Longitudinal predictors of bronchial hyperresponsiveness and FEVInternational archives of occupational and environmental health · 2021Article
- Genetic effects of allergen-specific IgE levels on exhaled nitric oxide in schoolchildren with asthma: The STOPPA twin study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Article
Corrections and comments
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Authors and funding
30 authors at 20 institutions in 13 countries.
Funding
Abstract
backgroundCross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect.
objectiveWe sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period.
methodsLevels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse.
resultsOver the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (-4.6%; 95% CI, -7.0% to -2.1%). The prevalence of sensitization to house dust mite (-4.3%; 95% CI, -6.0% to -2.6%) and cat (-2.1%; 95% CI, -3.6% to -0.7%) decreased more than sensitization to grass (-0.6%; 95% CI, -2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts.
conclusionAging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.
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