ReviewThe journal of physiological sciences : JPS2016
Somato-axodendritic release of oxytocin into the brain due to calcium amplification is essential for social memory.
Review in The journal of physiological sciences : JPS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Type III CD38 is present in the membrane of neurosecretory vesicles and has a cytosol-facing catalytic domain in primate oxytocin neurons.Journal of neuroendocrinology · 2026Article
- Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Remission of social behavior impairment by oral administration of a precursor of NAD in CD157, but not in CD38, knockout mice.Frontiers in immunology · 2023Article
- Behavioral, Neural, and Molecular Mechanisms of Conditioned Mate Preference: The Role of Opioids and First Experiences of Sexual Reward.International journal of molecular sciences · 2022Review
- Serum Oxytocin in Cows Is Positively Correlated with Caregiver Interactions in the Impossible Task Paradigm.Animals : an open access journal from MDPI · 2022Article
- Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside.Frontiers in neuroscience · 2022Review
- "Live together, die alone": The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress.Neurobiology of stress · 2021Article
- In Vivo Electrophysiology of Peptidergic Neurons in Deep Layers of the Lumbar Spinal Cord after Optogenetic Stimulation of Hypothalamic Paraventricular Oxytocin Neurons in Rats.International journal of molecular sciences · 2021Article
- Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord.Current biology : CB · 2021Article
- RAGE regulates oxytocin transport into the brain.Communications biology · 2020Review
- One Single Nucleotide Polymorphism of theDiseases (Basel, Switzerland) · 2020Article
- CD157 and Brain Immune System in (Patho)physiological Conditions: Focus on Brain Plasticity.Frontiers in immunology · 2020Review
- Review
- A multiscale analysis in CD38FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- A rat model for pituitary stalk electric lesion-induced central diabetes insipidus: application of 3D printing and further outcome assessments.Experimental animals · 2018Article
- Effects of Three Lipidated Oxytocin Analogs on Behavioral Deficits in CD38 Knockout Mice.Brain sciences · 2017Article
- Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience.Neuroscience and biobehavioral reviews · 2017Review
- An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator.BMC neuroscience · 2017Article
- Structure-specific effects of lipidated oxytocin analogs on intracellular calcium levels, parental behavior, and oxytocin concentrations in the plasma and cerebrospinal fluid in mice.Pharmacology research & perspectives · 2017Article
- Neurotransmitter release: vacuolar ATPase V0 sector c-subunits in possible gene or cell therapies for Parkinson's, Alzheimer's, and psychiatric diseases.The journal of physiological sciences : JPS · 2017Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxytocin (OT) is released into the brain from the cell soma, axons, and dendrites of neurosecretory cells in the hypothalamus. Locally released OT can activate OT receptors, form inositol-1,4,5-trisphosphate and elevate intracellular free calcium (Ca(2+)) concentrations [(Ca(2+)) i ] in self and neighboring neurons in the hypothalamus, resulting in further OT release: i.e., autocrine or paracrine systems of OT-induced OT release. CD38-dependent cyclic ADP-ribose (cADPR) is also involved in this autoregulation by elevating [Ca(2+)] i via Ca(2+) mobilization through ryanodine receptors on intracellular Ca(2+) pools that are sensitive to both Ca(2+) and cADPR. In addition, it has recently been reported that heat stimulation and hyperthermia enhance [Ca(2+)] i increases by Ca(2+) influx, probably through TRPM2 cation channels, suggesting that cADPR and TRPM2 molecules act as Ca(2+) signal amplifiers. Thus, OT release is not simply due to depolarization-secretion coupling. Both of these molecules play critical roles not only during labor and milk ejection in reproductive females, but also during social behavior in daily life in both genders. This was clearly demonstrated in CD38 knockout mice in that social behavior was impaired by reduction of [Ca(2+)] i elevation and subsequent OT secretion. Evidence for the associations of CD38 with social behavior and psychiatric disorder is discussed, especially in subjects with autism spectrum disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.