Evidence map›Paper›PMID 26585977›Full record

ReviewNature reviews. Neurology2015

Remote ischaemic conditioning-a new paradigm of self-protection in the brain.

David C Hess, Rolf A Blauenfeldt, Grethe Andersen, Kristina D Hougaard, Md Nasrul Hoda, Yuchuan Ding, Xunming Ji

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 137 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 9 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03375762 naunknown statusnot on this mapstarted 2019, after this paper: background citation

REMOTE Ischemic Perconditioning Among Acute Ischemic Stroke Patients in CATalonia: REMOTE-CAT PROJECT

TypeinterventionalSponsorInstitut de Recerca Biomèdica de LleidaRan2019 to 2024Enrolled572ConditionsIschemic StrokeArmsRemote ischemic perconditioning, Sham remote perconditioning
NCT03481777 nacompletednot on this mapstarted 2018, after this paper: background citation

Remote Ischemic Conditioning in Patients With Acute Stroke: a Multicenter Randomized, Patient-assessor Blinded, Sham-controlled Study

TypeinterventionalSponsorGrethe AndersenRan2018 to 2023Enrolled1,500ConditionsStroke, Acute, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral HemorrhageArmsRemote Ischemic Conditioning, Sham Remote Ischemic Conditioning
NCT06032533 narecruitingnot on this mapstarted 2023, after this paper: background citation

The Effect of Remote Ischemic Conditioning on Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: A Prospective, Randomized, Patient-assessor Blinded, Sham-controlled Pilot Study Investigating Effect on Clinical Outcome.

TypeinterventionalSponsorAarhus University HospitalRan2023 to 2027Enrolled100ConditionsSubarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral IschemiaArmsRemote Ischemic Conditioning with Automatic Tourniquet Device, Sham Remote Ischemic Conditioning with Automatic Tourniquet Device
3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 9 syntheses or guidelines pooled it, 222 citations in OpenAlex.

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  7. A meta-analysis of remote ischaemic conditioning in experimental stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

David C HessDepartment of Neurology, Medical College of Georgia, Georgia Regents University, 1120 15th Street Augusta, GA 30912, USA.
Rolf A BlauenfeldtDepartment of Neurology, Aarhus University Hospital, Norrebrogade 44, DK-8000, Aarhus C, Denmark.
Grethe AndersenDepartment of Neurology, Aarhus University Hospital, Norrebrogade 44, DK-8000, Aarhus C, Denmark.
Kristina D HougaardDepartment of Neurology, Aarhus University Hospital, Norrebrogade 44, DK-8000, Aarhus C, Denmark.
Md Nasrul HodaDepartment of Medical Laboratory, Imaging, and Radiologic Sciences, College of Allied Health Sciences, Georgia Regents University, 1120 15th Street Augusta, GA 30912, USA.
Yuchuan DingDepartment of Neurosurgery, Wayne State University, 4160 John R. Street, Suite 930, Detroit, MI 48201, USA.
Xunming JiXuanwu Hospital, Beijing Capital University, 45 Changchun Street, Xuanwu District, Beijing 100053, China.
Aarhus University Hospital · DKAugusta University · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant organs such as the kidney, heart and brain, and represents an exciting new paradigm in neuroprotection. RIC involves repetitive inflation and deflation of a blood pressure cuff on the limb, and is safe and feasible. The exact mechanism of signal transmission from the periphery to the brain is not known, but both humoral factors and an intact nervous system seem to have critical roles. Early-phase clinical trials have already been conducted to test RIC in the prehospital setting in acute ischaemic stroke, and in subarachnoid haemorrhage for the prevention of delayed cerebral ischaemia. Furthermore, two small randomized clinical trials in patients with symptomatic intracranial atherosclerosis have shown that RIC can reduce recurrence of stroke and have neuroprotective activity. RIC represents a highly practical and translatable therapy for acute, subacute, and chronic neurological diseases with an ischaemic or inflammatory basis. In this Review, we consider the principles and mechanisms of RIC, evidence from preclinical models and clinical trials that RIC is beneficial in neurological disease, and how the procedure might be used in the future in disorders such as vascular cognitive impairment and traumatic brain injury.

Indexed as

Brain IschemiaBrainHumansNervous System DiseasesNeuroprotectionSignal Transduction

Identifiers

PMID26585977
OpenAlexW2185943660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.