Evidence map›Paper›PMID 26585691›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2016

PTH Induces Systemically Administered Mesenchymal Stem Cells to Migrate to and Regenerate Spine Injuries.

Dmitriy Sheyn, Galina Shapiro, Wafa Tawackoli, Douk Soo Jun, Youngdo Koh, Kyu Bok Kang, Susan Su, Xiaoyu Da, Shiran Ben-David, Maxim Bez and 10 more

Erratum issuedOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 54 citations in OpenAlex.

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  12. Assessing the Resident Progenitor Cell Population and the Vascularity of the Adult Human Meniscus.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Dmitriy SheynDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Galina ShapiroSkeletal Biotech Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel.
Wafa TawackoliDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Douk Soo JunDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Youngdo KohDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Kyu Bok KangDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Susan SuDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Xiaoyu DaBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Shiran Ben-DavidDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Maxim BezSkeletal Biotech Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel.
Eran YalonSkeletal Biotech Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel.
Ben AntebiSkeletal Biotech Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel.
Pablo AvalosBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Tomer SternDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Elazar ZelzerDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Edward M SchwarzThe Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, USA; Department of Orthopedics, University of Rochester Medical Center, Rochester, New York, USA.
Zulma GazitDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Skeletal Biotech Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel.
Gadi PelledDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Skeletal Biotech Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel.
Hyun M BaeDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Dan GazitDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Skeletal Biotech Laboratory, Hebrew University of Jerusalem, Jerusalem, Israel; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: dan.gazit@csmc.edu.
Cedars-Sinai Medical Center · USHebrew University of Jerusalem · ILWeizmann Institute of Science · ILUniversity of Rochester Medical Center · US

Funding

Translating PTH Therapy as an Adjuvant for Structural AllograftingP50AR054041 · NIAMS · UNIVERSITY OF ROCHESTER · PI SCHWARZ, EDWARD M. · 2006 to 2016
$15.7M
PTH Effects of Craniofacial AllograftsR01DE019902 · NIDCR · UNIVERSITY OF ROCHESTER · PI GAZIT, DAN, SCHWARZ, EDWARD M. · 2009 to 2019
$5.0M
NIAMS NIH HHS P50 AR054041NIDCR NIH HHS R01 DE019902NIDCR NIH HHS R01DE019902
6 · The paper itself

Abstract

Osteoporosis affects more than 200 million people worldwide leading to more than 2 million fractures in the United States alone. Unfortunately, surgical treatment is limited in patients with low bone mass. Parathyroid hormone (PTH) was shown to induce fracture repair in animals by activating mesenchymal stem cells (MSCs). However, it would be less effective in patients with fewer and/or dysfunctional MSCs due to aging and comorbidities. To address this, we evaluated the efficacy of combination i.v. MSC and PTH therapy versus monotherapy and untreated controls, in a rat model of osteoporotic vertebral bone defects. The results demonstrated that combination therapy significantly increased new bone formation versus monotherapies and no treatment by 2 weeks (P < 0.05). Mechanistically, we found that PTH significantly enhanced MSC migration to the lumbar region, where the MSCs differentiated into bone-forming cells. Finally, we used allogeneic porcine MSCs and observed similar findings in a clinically relevant minipig model of vertebral defects. Collectively, these results demonstrate that in addition to its anabolic effects, PTH functions as an adjuvant to i.v. MSC therapy by enhancing migration to heal bone loss. This systemic approach could be attractive for various fragility fractures, especially using allogeneic cells that do not require invasive tissue harvest.

Indexed as

AnimalsBone RegenerationCell DifferentiationCell MovementCombined Modality TherapyDisease Models, AnimalFemaleHumansMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOsteoporosisParathyroid HormoneRatsSpinal FracturesSwineParathyroid Hormone

Identifiers

PMID26585691
PMCPMC4817819
OpenAlexW2295107161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.