Evidence map›Paper›PMID 26585411›Full record

Trial reportLeukemia2016

Quizartinib elicits differential responses that correlate with karyotype and genotype of the leukemic clone.

G E Nybakken, J Canaani, D Roy, J D Morrissette, C D Watt, N P Shah, C C Smith, A Bagg, M Carroll, A E Perl

Abstract readClinical Trial, Phase IILetter
In one paragraph

Trial report in Leukemia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Evaluation of hypereosinophilia in a case ofCold Spring Harbor molecular case studies · 2023
    Article
  14. Gilteritinib (XOSPATA®) in Turkey: Early Access Program Results.Mediterranean journal of hematology and infectious diseases · 2023
    Article
  15. Alterations toCancer research · 2021
    Review
  16. Article
  17. Review
  18. Article
  19. New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise.International journal of molecular sciences · 2019
    Review
  20. Classes of ITD Predict Outcomes in AML Patients Treated with FLT3 Inhibitors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

G E NybakkenDepartment of Pathology, Kaiser Permanente Santa Clara, CA, USA.
J CanaaniDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA.
D RoyDepartment of Pathology, Rowan University, Glassboro, NJ, USA.
J D MorrissetteDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
C D WattDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
N P ShahDepartment of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA, USA.
C C SmithDepartment of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA, USA.
A BaggDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
M CarrollDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA.
A E PerlDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Mechanisms of resistance to clinically-effective FLT3 kinase inhibitors in AMLR01CA166616 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHAH, NEIL P · 2012 to 2016
$1.6M
mTOR Inhibition as a Therapeutic Strategy for Acute Myeloid LeukemiaK23CA141054 · NCI · UNIVERSITY OF PENNSYLVANIA · PI PERL, ALEXANDER E. · 2010 to 2014
$862k
Investigating Resistance to FLT3 Inhibitors in AMLK08CA187577 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SMITH, CATHERINE CHOY · 2014 to 2017
$703k
How Does FLT3 Mutation Regulate Myeloid Differentiation in Acute Myeloid LeukemiaR21CA198621 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CARROLL, MARTIN · 2015 to 2016
$396k
NCI NIH HHS K08 CA187577NCI NIH HHS K23 CA141054NCI NIH HHS R01 CA166616NCI NIH HHS R21 CA198621
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

GenotypeKaryotypingBenzothiazolesfms-Like Tyrosine Kinase 3HumansLeukemia, Myeloid, AcuteMutationPhenylurea CompoundsBenzothiazolesFLT3 protein, humanfms-Like Tyrosine Kinase 3Phenylurea Compoundsquizartinib

Identifiers

PMID26585411
PMCPMC4927337

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.