Evidence map›Paper›PMID 26585267›Full record

ArticleAJNR. American journal of neuroradiology2016

White Matter Abnormality Correlates with Developmental and Seizure Outcomes in West Syndrome of Unknown Etiology.

J Natsume, C Ogawa, T Fukasawa, H Yamamoto, N Ishihara, Y Sakaguchi, Y Ito, T Takeuchi, Y Azuma, N Ando and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

J NatsumeFrom the Departments of Pediatrics (J.N., C.O., H.Y., N.I., Y.S., Y.I., T. Takeuchi, Y.A., H. Kidokoro) Developmental Disability Medicine (J.N.) Brain and Mind Research Center (J.N., H. Kidokoro), Nagoya University, Nagoya, Japan junnatsu@med.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0002-2081-9449
C OgawaFrom the Departments of Pediatrics (J.N., C.O., H.Y., N.I., Y.S., Y.I., T. Takeuchi, Y.A., H. Kidokoro).ORCID http://orcid.org/0000-0002-4246-3164
T FukasawaDepartment of Pediatrics (T.F., T.K.), Anjo Kosei Hospital, Anjo, Japan.ORCID http://orcid.org/0000-0002-3678-2601
H YamamotoFrom the Departments of Pediatrics (J.N., C.O., H.Y., N.I., Y.S., Y.I., T. Takeuchi, Y.A., H. Kidokoro).ORCID http://orcid.org/0000-0003-1109-5298
N IshiharaFrom the Departments of Pediatrics (J.N., C.O., H.Y., N.I., Y.S., Y.I., T. Takeuchi, Y.A., H. Kidokoro).ORCID http://orcid.org/0000-0002-1248-8010
Y SakaguchiFrom the Departments of Pediatrics (J.N., C.O., H.Y., N.I., Y.S., Y.I., T. Takeuchi, Y.A., H. Kidokoro).ORCID http://orcid.org/0000-0001-5211-610X
Y ItoFrom the Departments of Pediatrics (J.N., C.O., H.Y., N.I., Y.S., Y.I., T. Takeuchi, Y.A., H. Kidokoro).ORCID http://orcid.org/0000-0003-0460-9588
T TakeuchiFrom the Departments of Pediatrics (J.N., C.O., H.Y., N.I., Y.S., Y.I., T. Takeuchi, Y.A., H. Kidokoro).ORCID http://orcid.org/0000-0002-6006-5258
Y AzumaFrom the Departments of Pediatrics (J.N., C.O., H.Y., N.I., Y.S., Y.I., T. Takeuchi, Y.A., H. Kidokoro).ORCID http://orcid.org/0000-0002-5363-5638
N AndoDepartment of Pediatrics and Neonatology (N.A.), Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.ORCID http://orcid.org/0000-0002-8069-6129
T KubotaDepartment of Pediatrics (T.F., T.K.), Anjo Kosei Hospital, Anjo, Japan.ORCID http://orcid.org/0000-0003-4159-0054
T TsujiDepartment of Pediatrics (T. Tsuji), Okazaki City Hospital, Okazaki, Japan.ORCID http://orcid.org/0000-0002-5068-2359
H KawaiRadiology (H. Kawai, S.N.), Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0003-3789-4055
S NaganawaRadiology (H. Kawai, S.N.), Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0002-0214-613X
H KidokoroFrom the Departments of Pediatrics (J.N., C.O., H.Y., N.I., Y.S., Y.I., T. Takeuchi, Y.A., H. Kidokoro) Brain and Mind Research Center (J.N., H. Kidokoro), Nagoya University, Nagoya, Japan.ORCID http://orcid.org/0000-0002-7991-8580
Young Invincibles · USAnjo Kosei Hospital · JPNagoya University · JPDaido University · JPNagoya City University · JPNeuroDevelopment Center · USOkazaki City Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeWest syndrome is an epileptic encephalopathy characterized by epileptic spasms, a specific pattern on electroencephalography of hypsarrhythmia, and developmental regression. Our aim was to assess white matter abnormalities in West syndrome of unknown etiology. We hypothesized that diffusion tensor imaging reveals white matter abnormalities, especially in patients with poor seizure and developmental outcomes. MATERIALS AND

methodsWe enrolled 23 patients with new-onset West syndrome of unknown etiology. DTI was performed at 12 and 24 months of age. Fractional anisotropy images were compared with those of controls by using tract-based spatial statistics. We compared axial, radial, and mean diffusivity between patients and controls in the fractional anisotropy skeleton. We determined correlations of these parameters with developmental quotient, electroencephalography, and seizure outcomes. We also compared DTI with hypometabolism on fluorodeoxyglucose positron-emission tomography.

resultsAt 12 months of age, patients showed widespread fractional anisotropy reductions and higher radial diffusivity in the fractional anisotropy skeleton with a significant difference on tract-based spatial statistics. The developmental quotient at 12 months of age correlated positively with fractional anisotropy and negatively with radial and mean diffusivity. Patients with seizure and abnormal findings on electroencephalography after initial treatments had lower fractional anisotropy and higher radial diffusivity. At 24 months, although tract-based spatial statistics did not show significant differences between patients and controls, tract-based spatial statistics in the 10 patients with a developmental quotient of <70 had significant fractional anisotropy reduction. In patients with unilateral temporal lobe hypometabolism on PET, tract-based spatial statistics showed greater fractional anisotropy reduction in the temporal lobe ipsilateral to the side of PET hypometabolism.

conclusionsDiffuse abnormal findings on DTI at 12 months of age suggest delayed myelination as a key factor underlying abnormal findings on DTI. Conversely, asymmetric abnormal findings on DTI at 24 months may reflect underlying focal pathologies.

Indexed as

Adrenocorticotropic HormoneAnisotropyDevelopmental DisabilitiesDiffusion Tensor ImagingElectroencephalographyFemaleFluorodeoxyglucose F18HumansInfantMalePositron-Emission TomographyRadiopharmaceuticalsSeizuresSpasms, InfantileTreatment OutcomeWhite MatterAdrenocorticotropic HormoneFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID26585267
PMCPMC7960183
OpenAlexW2176888361

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.