Evidence map›Paper›PMID 26585263›Full record

ArticleAJNR. American journal of neuroradiology2016

Radiologic Features and Expression of Vascular Endothelial Growth Factor Stratify Survival Outcomes in Patients with Glioblastoma.

K Wang, Y Y Wang, J F Wang, J Ma, T Jiang, J P Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

K WangFrom the Departments of Neuroradiology (K.W., J.M., J.P.D.).ORCID http://orcid.org/0000-0002-2471-5460
Y Y WangNeurosurgery (Y.Y.W., J.F.W., T.J.), Beijing Tiantan Hospital Beijing Neurosurgical Institute (Y.Y.W., T.J., J.P.D.), Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0001-5665-5178
J F WangNeurosurgery (Y.Y.W., J.F.W., T.J.), Beijing Tiantan Hospital Beijing Neurosurgical Institute (Y.Y.W., T.J., J.P.D.), Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0001-8793-3409
J MaFrom the Departments of Neuroradiology (K.W., J.M., J.P.D.).ORCID http://orcid.org/0000-0002-5408-6386
T JiangNeurosurgery (Y.Y.W., J.F.W., T.J.), Beijing Tiantan Hospital Beijing Neurosurgical Institute (Y.Y.W., T.J., J.P.D.), Capital Medical University, Beijing, China Beijing Institute for Brain Disorders (T.J.), Brain Tumor Center, Beijing, China. djpbeijing@hotmail.com taojiang1964@163.com.ORCID http://orcid.org/0000-0002-7008-6351
J P DaiFrom the Departments of Neuroradiology (K.W., J.M., J.P.D.) Beijing Neurosurgical Institute (Y.Y.W., T.J., J.P.D.), Capital Medical University, Beijing, China djpbeijing@hotmail.com taojiang1964@163.com.ORCID http://orcid.org/0000-0002-5584-9031

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeVascular endothelial growth factor is a well-known tumor-specific biomarker that mediates angiogenesis in glioblastoma via hypoxia-dependent mechanisms. Our aim was to investigate the correlation of clinical characteristics, radiologic features, and vascular endothelial growth factor expression with survival outcomes in patients with glioblastoma. MATERIALS AND

methodsClinical and radiologic data of 185 patients with glioblastoma were retrospectively reviewed. Vascular endothelial growth factor expression was examined in all cases via immunohistochemical analysis. Univariate and multivariate analyses were performed to identify the prognostic factors of progression-free survival and overall survival.

resultsVascular endothelial growth factor expression levels were associated with the presence of ringlike tumor contrast enhancement. Age, preoperative Karnofsky Performance Scale score, gross total resection, and adjuvant therapy were identified as prognostic factors. Among patients undergoing gross total resection, high vascular endothelial growth factor expression was associated with longer progression-free survival (P = .011) and overall survival (P = .039). For tumors with high vascular endothelial growth factor expression, both the non-contrast-enhancing tumor component and peritumoral edema could stratify overall survival (P = .039 and .018, respectively), while only the presence of the non-contrast-enhancing tumor component predicted a longer progression-free survival (P = .024).

conclusionsVascular endothelial growth factor expression level was not an independent prognostic factor in glioblastoma. However, high vascular endothelial growth factor expression might predict longer survival in patients in whom gross total resection was achieved. Furthermore, peritumoral edema and the non-contrast-enhancing tumor component could stratify survival outcomes in patients with high vascular endothelial growth factor tumors.

Indexed as

AdolescentAdultAgedBiomarkers, TumorBrain NeoplasmsCombined Modality TherapyDisease-Free SurvivalFemaleGlioblastomaHumansMaleMiddle AgedMultivariate AnalysisNeovascularization, PathologicPrognosisRetrospective StudiesBiomarkers, TumorVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID26585263
PMCPMC7960168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.