Evidence map›Paper›PMID 26585195›Full record

ReviewDifferentiation; research in biological diversity

Methods for studying human organogenesis.

Gerald Cunha, Maya Overland, Yi Li, Mei Cao, Joel Shen, Adriane Sinclair, Laurence Baskin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Differentiation; research in biological diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gerald CunhaDepartment of Urology, University of California San Francisco, 400 Parnassus Avenue, Box A610, San Francisco, CA 94143, USA. Electronic address: gerald.cunha@ucsf.edu.
Maya OverlandDepartment of Urology, University of California San Francisco, 400 Parnassus Avenue, Box A610, San Francisco, CA 94143, USA.
Yi LiDepartment of Urology, University of California San Francisco, 400 Parnassus Avenue, Box A610, San Francisco, CA 94143, USA.
Mei CaoDepartment of Urology, University of California San Francisco, 400 Parnassus Avenue, Box A610, San Francisco, CA 94143, USA.
Joel ShenDepartment of Urology, University of California San Francisco, 400 Parnassus Avenue, Box A610, San Francisco, CA 94143, USA.
Adriane SinclairDepartment of Urology, University of California San Francisco, 400 Parnassus Avenue, Box A610, San Francisco, CA 94143, USA.
Laurence BaskinDepartment of Urology, University of California San Francisco, 400 Parnassus Avenue, Box A610, San Francisco, CA 94143, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
UCSF KURe Career Development ProgramK12DK083021 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASKIN, LAURENCE, CARROLL, PETER R · 2008 to 2017
$5.9M
Hypospadias Differentiation and Endocrine DisruptorsR01DK058105 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASKIN, LAURENCE · 2003 to 2015
$2.7M
NIDDK NIH HHS K12 DK083021NIDDK NIH HHS R01 DK058105NIGMS NIH HHS T32 GM007618
6 · The paper itself

Abstract

This review details methods for utilizing D & C suction abortus specimens as a source of human fetal organs to study the morphogenetic and molecular mechanisms of human fetal organ development. By this means it is possible to design experiments elucidating the molecular mechanisms of human fetal organ development and to compare and contrast human developmental mechanisms with that of laboratory animals. Finally human fetal organs can be grown in vivo as grafts to athymic mice, thus allowing ethical analysis of potential adverse effects of environmental toxicants.

Indexed as

Aborted FetusAnimalsCell DifferentiationEcotoxicologyGene Expression Regulation, DevelopmentalHumansMiceOrganogenesisHuman developmentInternal genitaliaMale and female external genitalia

Identifiers

PMID26585195
PMCPMC4866906

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.