ArticleJournal of assisted reproduction and genetics2016
Association of polymorphisms in tektin-t gene with idiopathic asthenozoospermia in Sichuan, China.
Article in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Cross-omics association of small extracellular vesicle miRNAs and metabolites in seminal plasma of idiopathic male infertility.Frontiers in endocrinology · 2026Article
- Article
- Investigation of the association of endothelial nitric oxide synthase (eNOS)-T786C gene polymorphism with the risk of male infertility in an Iranian population.Environmental science and pollution research international · 2020Article
- Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2-related factor 2 activation.Andrologia · 2020Article
- Association ofBioscience reports · 2019Article
- Association of GRP78 promoter polymorphisms and serum GRP78 level with risk of asthenozoospermia.Journal of assisted reproduction and genetics · 2018Article
- The axoneme: the propulsive engine of spermatozoa and cilia and associated ciliopathies leading to infertility.Journal of assisted reproduction and genetics · 2016Review
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this research was to study the association between the single nucleotide polymorphisms (SNPs) of the tektin-t gene and idiopathic asthenozoospermia.
methodsWe conducted sequence analyses of the tektin-t gene in 104 idiopathic asthenozoospermia and 102 fertile men with normospermic parameters in Sichuan, China.
resultsIn this study, we found that allele 136 T (odds ratio [OR] 1.745, 95 % confidence interval [CI] 1.146-2.655, P = 0.009) was significantly increased in idiopathic asthenozoospermic patients compared with fertile men. This mutation substitutes a highly conserved arginine at position 46 to cysteine. Moreover, PolyPhen-2 analysis predicted that this variant was "probably damaging". In addition, a novel heterozygous mutation, R207H (c.620G >A), was detected in five asthenozoospermic patients, while there was no detection of this genotype among the fertile candidates, indicating that the mutation was located within a conserved domain predicted by PolyPhen-2 analysis as "probably damaging" to the protein.
conclusionsThese results suggested that tektin-t variants (Arg/Cys + Cys/Cys) were probably one of the high risk genetic factors for idiopathic asthenozoospermia among males in Sichuan, China, while the R207H polymorphism may be associated with idiopathic asthenozoospermia risk.
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