Observational studyObesity (Silver Spring, Md.)2016
Greater hunger and less restraint predict weight loss success with phentermine treatment.
Observational study in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Evaluating potential predictors of weight loss response to liraglutide in adolescents with obesity: A post hoc analysis of the randomized, placebo-controlled SCALE Teens trial.Pediatric obesity · 2023Trial
- Early time-restricted eating compared with daily caloric restriction: A randomized trial in adults with obesity.Obesity (Silver Spring, Md.) · 2022Trial
- Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial.Scientific reports · 2019Trial
- Trial
- Lower incidence of diabetic retinopathy and worsening events after phentermine assisted weight loss across a large U.S. cohort.Eye (London, England) · 2025Article
- Old and new anti-obesity drugs.Journal of diabetes and metabolic disorders · 2025Review
- Review
- Phentermine in the Modern Era of Obesity Pharmacotherapy: Does It Still Have a Role in Treatment?Current obesity reports · 2024Review
- Appetitive and Metabolic Responses to an Exercise versus Dietary Intervention in Adults with Obesity.Translational journal of the American College of Sports Medicine · 2022Article
- Neurochemical regulators of food behavior for pharmacological treatment of obesity: current status and future prospects.Future medicinal chemistry · 2020Review
- Precision medicine in adult and pediatric obesity: a clinical perspective.Therapeutic advances in endocrinology and metabolism · 2019Review
- Article
- Off-label drugs for weight management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2017Review
- Pharmacologic Approaches to Weight Management: Recent Gains and Shortfalls in Combating Obesity.Current atherosclerosis reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivePhentermine is thought to cause weight loss through a reduction in hunger. It was hypothesized that higher hunger ratings would predict greater weight loss with phentermine.
methodsThis is an observational pilot study in which all subjects were treated with phentermine for 8 weeks and appetite and eating behaviors were measured at baseline and week 8. Outcomes were compared in subjects with ≥5% vs. <5% weight loss, and linear regression was used to identify predictors of percent weight loss.
resultsTwenty-seven subjects (37 ± 4.5 years, 93.8 ± 12.1 kg, BMI 33.8 ± 3.1 kg m(-2) ) completed the study, with mean weight loss of -5.4 ± 3.3 kg (-5.7% ± 3.2%). Subjects with ≥5% weight loss had higher baseline pre-breakfast hunger (P = 0.017), desire to eat (P =0.003), and prospective food consumption (0.006) and lower baseline cognitive restraint (P = 0.01). In addition, higher baseline home prospective food consumption (P = 0.002) and lower baseline cognitive restraint (P < 0.001) were found to be predictors of weight loss.
conclusionsThese results suggest that individuals reporting greater hunger and less restraint are more likely to achieve significant weight loss with phentermine. This information can be used clinically to determine who might benefit most from phentermine treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.