ArticleStem cell reports2015
Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study.
Article in Stem cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Comprehensive characterization of spinal ependymomas in NF2-Schwannomatosis.Acta neuropathologica communications · 2026Article
- Triplet pregnancies after single blastocyst embryo transfer-how often and why do these occur?Journal of assisted reproduction and genetics · 2025Article
- Cellular mechanisms of monozygotic twinning: clues from assisted reproduction.Human reproduction update · 2024Review
- Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity.Cellular and molecular life sciences : CMLS · 2023Article
- A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner.Cell reports · 2023Article
- In mice and humans, brain microvascular contractility matures postnatally.Brain structure & function · 2023Article
- Lab partners: oocytes, embryos and company. A personal view on aspects of oocyte maturation and the development of monozygotic twins.Animal reproduction · 2023Article
- Cortical wiring by synapse type-specific control of local protein synthesis.Science (New York, N.Y.) · 2022Article
- A conserved molecular template underlies color pattern diversity in estrildid finches.Science advances · 2022Article
- On the origin of zygosity and chorionicity in twinning: evidence from human in vitro fertilization.Journal of assisted reproduction and genetics · 2021Review
- Mechanobiology of the female reproductive system.Reproductive medicine and biology · 2021Review
- Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.Molecular psychiatry · 2021Article
- Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.Molecular neurobiology · 2021Article
- Stepwise target controllability identifies dysregulations of macrophage networks in multiple sclerosis.Network neuroscience (Cambridge, Mass.) · 2021Article
- Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.Nature neuroscience · 2020Article
- Cardiac Anomalies in Liveborn and Stillborn Monochorionic Twins.Clinical medicine & research · 2020Article
- Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.Nature communications · 2020Article
- Mechanisms of human embryo development: from cell fate to tissue shape and back.Development (Cambridge, England) · 2020Review
- Effects of a Single Head Exposure to GSM-1800 MHz Signals on the Transcriptome Profile in the Rat Cerebral Cortex: Enhanced Gene Responses Under Proinflammatory Conditions.Neurotoxicity research · 2020Article
- Effects of thyroid hormone on mitochondria and metabolism of human preimplantation embryos.Stem cells (Dayton, Ohio) · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Discordant growth is a common complication of monochorionic/diamniotic pregnancies; in approximately 50% of cases, the cause is unknown. The case presented here suggests that discordant growth of monozygotic twins could start during preimplantation development. Two inner cell masses (ICMs) within the same blastocyst may originate in uneven splitting of a single "parental" ICM, or the two ICMs may be formed independently de novo. We studied the transcriptomes of two morphologically distinct ICMs within a single blastocyst using high-resolution RNA sequencing. The data indicated that the two ICM were at different stages of development; one was in the earliest stages of lineage commitment, while the other had already differentiated into epiblast and primitive endoderm. IGF1-mediated signaling is likely to play a key role in ICM growth and to be the major driver behind these differences.
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