ArticleAmerican journal of respiratory cell and molecular biology2016
Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Article in American journal of respiratory cell and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Trial
- Prenatal Household Air Pollution Is Associated with Impaired Infant Lung Function with Sex-Specific Effects. Evidence from GRAPHS, a Cluster Randomized Cookstove Intervention Trial.American journal of respiratory and critical care medicine · 2019Trial
- Sex-specific in utero reprogramming of lung immunity.Mucosal immunology · 2026Article
- Sex and the Developmental Environment Shape Molecular Networks Underlying Bronchial Responsiveness in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Association of early VEGF trajectories with bronchopulmonary dysplasia severity in preterm infants.Scientific reports · 2025Observational
- Bulk RNA sequencing of human pediatric lung cell populations reveals unique transcriptomic signature associated with postnatal pulmonary development.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Identifying sensitive windows of prenatal household air pollution on birth weight and infant pneumonia risk to inform future interventions.Environment international · 2023Article
- A bioinformatics approach towards bronchopulmonary dysplasia.Translational pediatrics · 2023Review
- Intrauterine Smoke Exposure, microRNA Expression during Human Lung Development, and Childhood Asthma.International journal of molecular sciences · 2023Article
- FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies.Human molecular genetics · 2023Article
- Article
- Sex-Specific Differences in MicroRNA Expression During Human Fetal Lung Development.Frontiers in genetics · 2022Article
- Prenatal Ambient Ultrafine Particle Exposure and Childhood Asthma in the Northeastern United States.American journal of respiratory and critical care medicine · 2021Article
- Sex and Gender Omic Biomarkers in Men and Women With COPD: Considerations for Precision Medicine.Chest · 2021Review
- Age and Sex-Related Changes in Human First-Trimester Placenta Transcriptome and Insights into Adaptative Responses to Increased Oxygen.International journal of molecular sciences · 2021Article
- Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD.The European respiratory journal · 2020Article
- Whole exome sequencing analysis in severe chronic obstructive pulmonary disease.Human molecular genetics · 2018Article
- Genomics, microbiomics, proteomics, and metabolomics in bronchopulmonary dysplasia.Seminars in perinatology · 2018Review
- Human lung development: recent progress and new challenges.Development (Cambridge, England) · 2018Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The fetal origins of disease hypothesis suggests that variations in the course of prenatal lung development may affect life-long pulmonary function growth, decline, and pathobiology. Many studies support the existence of differences in the developing lung trajectory in males and females, and sex-specific differences in the prevalence of chronic lung diseases, such as asthma and bronchopulmonary dysplasia. The objectives of this study were to investigate the early developing fetal lung for transcriptomic correlates of postconception age (maturity) and sex, and their associations with chronic lung diseases. We analyzed whole-lung transcriptome profiles of 61 females and 78 males at 54-127 days postconception (dpc) from nonsmoking mothers using unsupervised principal component analysis and supervised linear regression models. We identified dominant transcriptomic correlates for postconception age and sex with corresponding gene sets that were enriched for developing lung structural and functional ontologies. We observed that the transcriptomic sex difference was not a uniform global time shift/lag, rather, lungs of males appear to be more mature than those of females before 96 dpc, and females appear to be more mature than males after 96 dpc. The age correlate gene set was consistently enriched for asthma and bronchopulmonary dysplasia genes, but the sex correlate gene sets were not. Despite sex differences in the developing fetal lung transcriptome, postconception age appears to be more dominant than sex in the effect of early fetal lung developments on disease risk during this early pseudoglandular phase of development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.