Evidence map›Paper›PMID 26583943›Full record

ReviewJournal of perinatology : official journal of the California Perinatal Association2016

Cardiorespiratory events in preterm infants: interventions and consequences.

J M Di Fiore, C F Poets, E Gauda, R J Martin, P MacFarlane

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05451953 (Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05451953 nacompletednot on this mapstarted 2022, after this paper: background citation

Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU

TypeinterventionalSponsorUniversity of PennsylvaniaRan2022 to 2026Enrolled110ConditionsNeonatal Respiratory Failure, Tracheal Intubation MorbidityArmsApneic Oxygenation, Standard of Care
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Titrating cumulative neonatal hyperoxia in mice to model bronchopulmonary dysplasia severities.American journal of respiratory cell and molecular biology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Observational
  9. Immature control of breathing and apnea of prematurity: the known and unknown.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Review
  10. Review
  11. Predicting Apnoeic Events in Preterm Infants.Frontiers in pediatrics · 2020
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

J M Di FioreDivision of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
C F PoetsDepartment of Neonatology, Tübingen University Hospital, Tübingen, Germany.
E GaudaDepartment of Pediatrics, Division of Neonatology, Johns Hopkins University, Baltimore, MD, USA.
R J MartinDivision of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
P MacFarlaneDivision of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Rainbow Babies & Children's Hospital · USCase Western Reserve University · USJohns Hopkins University · USUniversity Children's Hospital Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stabilization of respiration and oxygenation continues to be one of the main challenges in clinical care of the neonate. Despite aggressive respiratory support including mechanical ventilation, continuous positive airway pressure, oxygen and caffeine therapy to reduce apnea and accompanying intermittent hypoxemia, the incidence of intermittent hypoxemia events continues to increase during the first few months of life. Even with improvements in clinical care, standards for oxygen saturation targeting and modes of respiratory support have yet to be identified in this vulnerable infant cohort. In addition, we are only beginning to explore the association between the incidence and pattern of cardiorespiratory events during early postnatal life and both short- and long-term morbidity including retinopathy of prematurity, growth, sleep-disordered breathing and neurodevelopmental impairment. Part 1 of this review included a summary of lung development and diagnostic methods of cardiorespiratory monitoring. In Part 2 we focus on clinical interventions and the short- and long-term consequences of cardiorespiratory events in preterm infants.

Indexed as

Continuous Positive Airway PressureAnimalsApneaBradycardiaCaffeineCentral Nervous System StimulantsHumansHypoxiaInfant, NewbornInfant, PrematureInfant, Premature, DiseasesLungOxygenRespiration, ArtificialRetinopathy of PrematurityCaffeineCentral Nervous System StimulantsOxygen

Identifiers

PMID26583943
OpenAlexW2225959205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.