Trial reportJournal of perinatology : official journal of the California Perinatal Association2016
To evaluate and compare the efficacy of combined sucrose and non-nutritive sucking for analgesia in newborns undergoing minor painful procedure: a randomized controlled trial.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 8 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Effect of multisensory stimuli on neonatal pain during blood sample collection: a network meta-analysis of randomized controlled trials.European journal of pediatrics · 2025Pooled it
- Sucrose analgesia for heel-lance procedures in neonates.The Cochrane database of systematic reviews · 2023Pooled it
- Non-pharmacological management of infant and young child procedural pain.The Cochrane database of systematic reviews · 2023Pooled it
- Effect of Non-Pharmacological Methods in the Reduction of Neonatal Pain: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Pooled it
- Development of locally relevant clinical guidelines for procedure-related neonatal analgesic practice in Kenya: a systematic review and meta-analysis.The Lancet. Child & adolescent health · 2020Pooled it
- Pooled it
- Sucrose for analgesia in newborn infants undergoing painful procedures.The Cochrane database of systematic reviews · 2016Pooled it
- The effect of combined non-pharmacological interventions on venous blood sampling pain in preterm infants: a clinical trial study.BMC pediatrics · 2025Trial
- Effect of eye shield and ear muffs on pain intensity during venous blood sampling in premature infants: a clinical trial study.BMC pediatrics · 2023Trial
- New perspective for pain control in neonates: a comparative effectiveness research.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Trial
- Neonatal vascular access: management of pain and distress during vascular access device placement.Pediatric research · 2026Article
- Enhancing neonatal vascular access: proposing a patient-centered framework based on 7-Rights.Pediatric research · 2026Article
- Efficacy of expressed breast milk, facilitated tucking, and their combination for pain management during heel stick in preterm neonates: a randomized controlled trial.Frontiers in pediatrics · 2025Article
- [Expert consensus on neonatal pain assessment and analgesia management (2020 edition)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Oral 24% sucrose associated with nonnutritive sucking for pain control in healthy term newborns receiving venipuncture beyond the first week of life.Journal of pain research · 2019Article
- Health outcomes of non-nutritive sweeteners: analysis of the research landscape.Nutrition journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to evaluate and compare the efficacy of combined sucrose and non-nutritive sucking (NNS) for analgesia in newborn infants undergoing heel-stick procedures. STUDY
designThis randomized control trial was conducted in the neonatal intensive care unit of a tertiary care hospital over a period of 1 year. One hundred and eighty full-term neonates with birth weight >2200 g and age >24 h were randomized to one of four interventions administered 2 min before the procedure: 2 ml of 30% sucrose (group I, n=45) or NNS (group II, n=45) or both (group III, n=45) or none (group IV, n=45). Primary outcome was composite score based on Premature Infant Pain Profile (PIPP) score.
resultBaseline variables were comparable among the groups. Median (interquartile range) PIPP score was 3 (2 to 4) in group III as compared with 7 (6.5 to 8) in group I, 9 (7 to 11) in group II and 13 (10.5 to 15) in group IV. Group III had significant decrease in the median PIPP score compared with other groups (P=0.000). Median PIPP score also decreased significantly with any intervention as compared with no intervention (P=0.000).
conclusionSucrose and/or NNS are effective in providing analgesia in full-term neonates undergoing heel-stick procedures, with the combined intervention being more effective compared with any single intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.