ArticleEpidemiology (Cambridge, Mass.)2016
Amyotrophic Lateral Sclerosis and the Military: A Population-based Study in the Danish Registries.
Article in Epidemiology (Cambridge, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Risk factors associated with amyotrophic lateral sclerosis based on the observational study: a systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Military service and related risk factors for amyotrophic lateral sclerosis.Acta neurologica Scandinavica · 2021Pooled it
- Environmental toxins in neurodegeneration - a narrative review.Neurological research and practice · 2025Review
- Occupational history associates with ALS survival and onset segment.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2023Article
- A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: identifying exposures determining higher ALS risk.Journal of neurology · 2022Review
- Pregnancy loss and risk of multiple sclerosis and autoimmune neurological disorder: A nationwide cohort study.PloS one · 2022Article
- Incidence of and Mortality From Amyotrophic Lateral Sclerosis in National Football League Athletes.JAMA network open · 2021Observational
- Risk of Amyotrophic Lateral Sclerosis and Exposure to Particulate Matter from Vehicular Traffic: A Case-Control Study.International journal of environmental research and public health · 2021Article
- Environmental and Occupational Risk Factors of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study.International journal of environmental research and public health · 2020Article
- ALS in Danish Registries: Heritability and links to psychiatric and cardiovascular disorders.Neurology. Genetics · 2020Article
- Therapeutic Approaches Targeting Protein Aggregation in Amyotrophic Lateral Sclerosis.Frontiers in molecular neuroscience · 2020Review
- Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis.NPJ genomic medicine · 2020Article
- Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark.Occupational and environmental medicine · 2019Article
- Amyotrophic Lateral Sclerosis and Exposure to Diesel Exhaust in a Danish Cohort.American journal of epidemiology · 2018Article
- Intramuscular Delivery of scAAV9-hIGF1 Prolongs Survival in the hSOD1Molecular neurobiology · 2018Article
- Occupational formaldehyde and amyotrophic lateral sclerosis.European journal of epidemiology · 2017Article
- Military Service and Amyotrophic Lateral Sclerosis in a Population-based Cohort: Extended Follow-up 1979-2011.Epidemiology (Cambridge, Mass.) · 2017Article
- Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders.Pharmacology & therapeutics · 2016Review
- Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis etiology.Environment international · 2016Article
- Traumatic Brain Injury and Risk of Amyotrophic Lateral Sclerosis Mortality: A Traumatic Brain Injury Model Systems Study.Neurotrauma reportsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrior studies have suggested that military service may be associated with the development of amyotrophic lateral sclerosis (ALS). We conducted a population-based case-control study in Denmark to assess whether occupation in the Danish military is associated with an increased risk of developing ALS.
methodsThere were 3,650 incident cases of ALS recorded in the Danish National Patient Registry between 1982 and 2009. Each case was matched to 100 age- and sex-matched population controls alive and free of ALS on the date of the case diagnosis. Comprehensive occupational history was obtained from the Danish Pension Fund database, which began in 1964.
results2.4% (n = 8,922) of controls had a history of employment in the military before the index date. Military employees overall had an elevated rate of ALS (odds ratio [OR] = 1.3; 95% confidence interval [CI]: 1.1, 1.6). A 10-year increase in years employed by the military was associated with an OR of 1.2 (95% CI: 1.0, 1.4), and all quartiles of time employed were elevated. There was little suggestion of a pattern across calendar year of first employment, but there was some evidence that increasing age at first employment was associated with increased ALS rates. Rates were highest in the decade immediately following the end of employment (OR = 1.6; 95% CI: 1.2, 2.2).
conclusionsIn this large population-based case-control study, employment by the military is associated with increased rates of ALS. These findings are consistent with earlier findings that military service or employment may entail exposure to risk factors for ALS.
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