ReviewWorld journal of surgery
Do all colorectal carcinomas arise in preexisting adenomas?
Review in World journal of surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- One in three adenomas could be missed by white-light colonoscopy - findings from a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- A Focused Review on Advances in Risk Stratification of Malignant Polyps.Gastroenterology research · 2020Review
- Characteristics of minute T1 colorectal cancer in relevance to pathology and treatment.Annals of surgical treatment and research · 2020Article
- Article
- Risk factors for delayed post-polypectomy bleeding.Intestinal research · 2015Article
- Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors.International journal of molecular sciences · 2015Article
- A comparative overview of general risk factors associated with the incidence of colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Review
- HNPCC-associated synchronous early-stage signet-ring cell carcinomas of colonic origin. A comparative morphological and immunohistochemical study of an intramucosal and a submucosal example.Virchows Archiv : an international journal of pathology · 2009Article
- Increasing prevalence of advanced colonic polyps in young patients undergoing colonoscopy in a referral academic hospital in Hong Kong.World journal of gastroenterology · 2007Article
- Primary signet-ring cell carcinoma of the colon at early stage: a case report and a review of the literature.World journal of gastroenterology · 2006Review
- Feasibility study of colonoscopy as the primary screening investigation in relatives of patients with colorectal cancer.Annals of the Royal College of Surgeons of England · 2001Article
- Article
- Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer.The American journal of pathology · 1999Article
- Risk factors for self-reported colon polyps.Journal of general internal medicine · 1998Article
- Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer.British journal of cancer · 1997Article
- Recent and past physical activity and prevalence of colorectal adenomas.British journal of cancer · 1997Article
- The causes of ordinary colorectal adenomas: the key to the control of colorectal cancer?Journal of the Royal Society of Medicine · 1995Review
- Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel.Virchows Archiv : an international journal of pathology · 1995Article
- Article
- Morphometric analysis of colonic adenomatous polyps.Japanese journal of cancer research : Gann · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this article, the underlying nature of the adenoma is defined and evidence in support of the adenoma-carcinoma sequence is presented. Emphasis is placed on recent findings from the field of molecular biology which fortify the concept of the adenoma as a step in the evolution of large bowel cancer. Despite the considerable body of indirect evidence in support of the adenoma-carcinoma sequence, the de novo theory still has some support. Although differences between the de novo and adenoma carcinoma concept are largely semantic, the fact that infiltrating carcinoma can arise within small, flat foci of severely dysplastic epithelium (indistinguishable from carcinoma in situ) may be of considerable clinical importance. Other routes of morphogenesis exist also, but these make a relatively small contribution to the overall incidence of colorectal cancer. Even if it is accepted that the majority of colorectal cancers develop in a preexisting adenoma, the systematic removal of adenomas would pose a number of practical difficulties. First, adenomas are extremely common, particularly in populations at high risk of colorectal cancer. A second factor is the recently recognized existence of flat or depressed adenomas which may be small and difficult to visualize endoscopically. A simple screening program based on our knowledge of the evolution of colorectal cancer is outlined.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.