Evidence map›Paper›PMID 26583115›Full record

ReviewBioMed research international2015

T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome.

C B Larmonier, K W Shehab, F K Ghishan, P R Kiela

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 58 citations in OpenAlex.

  1. Exploration (Beijing, China) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Effects of Milk Replacer-BasedMicrobiology spectrum · 2022
    Article
  12. Review
  13. Article
  14. Frontiers in immunology · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Intestinal Regulatory T Cells.Advances in experimental medicine and biology · 2021
    Article
  20. New Insights on CD8Frontiers in immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

C B LarmonierDepartment of Pediatrics, Steele Children's Research Center, University of Arizona, Tucson, AZ 85724, USA.
K W ShehabDepartment of Pediatrics, Steele Children's Research Center, University of Arizona, Tucson, AZ 85724, USA.
F K GhishanDepartment of Pediatrics, Steele Children's Research Center, University of Arizona, Tucson, AZ 85724, USA.
P R KielaDepartment of Pediatrics, Steele Children's Research Center, University of Arizona, Tucson, AZ 85724, USA ; Department of Immunobiology, University of Arizona, Tucson, AZ 85724, USA.
University of Arizona · US

Funding

DEVELOPMENT OF INTESTINAL ION TRANSPORTR01DK041274 · NIDDK · VANDERBILT UNIVERSITY · PI GHISHAN, FAYEZ KHALAF, KIELA, PAWEL R · 1988 to 2016
$5.5M
The pathogenic role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental coK01DK099268 · NIDDK · UNIVERSITY OF ARIZONA · PI LARMONIER, CLAIRE · 2013 to 2014
$230k
NIDDK NIH HHS 1K01DK099268-01NIDDK NIH HHS 5R01 DK041274NIDDK NIH HHS R01 DK041274
6 · The paper itself

Abstract

Humans have coevolved with a complex community of bacterial species also referred to as the microbiome, which reciprocally provides critical contributions to human metabolism and immune system development. Gut microbiome composition differs significantly between individuals depending on host genetics, diet, and environmental factors. A dysregulation of the symbiotic nature of the intestinal host-microbial relationship and an aberrant and persistent immune response are the fundamental processes involved in inflammatory bowel diseases (IBD). Considering the essential role of T cells in IBD and the contributing role of the microbiome in shaping the immune response during the pathogenesis of IBD, this review focuses on the complex relationship, interplay, and communication between the gut microbiome and T cells, including their differentiation into different subsets of effector or regulatory cells.

Indexed as

Immune ToleranceGastrointestinal MicrobiomeHumansInflammatory Bowel DiseasesIntestinal MucosaSymbiosisT-LymphocytesT-Lymphocyte Subsets

Identifiers

PMID26583115
PMCPMC4637034
OpenAlexW2113732215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.