ArticleFrontiers in microbiology2015
Whole genome investigation of a divergent clade of the pathogen Streptococcus suis.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Genomic re-evaluation of clinical isolates reveals a structuredJournal of clinical microbiology · 2025Article
- Pan-immune system, mobilome and resistome inMicrobial genomics · 2025Article
- Virulence genes, resistome and mobilome ofMicrobial genomics · 2024Article
- The emergence and diversification of a zoonotic pathogen from within the microbiota of intensively farmed pigs.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transcriptomics in serum and culture medium reveal shared and differential gene regulation in pathogenic and commensalMicrobial genomics · 2023Article
- Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2Microbial genomics · 2022Article
- Phylogenies of the 16S rRNA gene and its hypervariable regions lack concordance with core genome phylogenies.Microbiome · 2022Article
- Genome Reduction Is Associated with Bacterial Pathogenicity across Different Scales of Temporal and Ecological Divergence.Molecular biology and evolution · 2021Article
- Genomic Characterization ofFrontiers in microbiology · 2021Article
- Update onPathogens (Basel, Switzerland) · 2020Article
- Molecular typing of Streptococcus suis strains isolated from diseased and healthy pigs between 1996-2016.PloS one · 2019Article
- Massive Diversity in Whole-Genome Sequences of Streptococcus suis Strains from Infected Pigs in Switzerland.Microbiology resource announcements · 2019Article
- Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distribution.Nucleic acids research · 2018Article
- SssP1, a Streptococcus suis Fimbria-Like Protein Transported by the SecY2/A2 System, Contributes to Bacterial Virulence.Applied and environmental microbiology · 2018Article
- Effects of Environmental and Management-Associated Factors on Prevalence and Diversity of Streptococcus suis in Clinically Healthy Pig Herds in China and the United Kingdom.Applied and environmental microbiology · 2018Article
- Exploring target-specific primer extension in combination with a bead-based suspension array for multiplexed detection and typing using Streptococcus suis as a model pathogen.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018Article
- Contribution of NADH oxidase to oxidative stress tolerance and virulence of Streptococcus suis serotype 2.Virulence · 2017Article
- Current Taxonomical Situation of Streptococcus suis.Pathogens (Basel, Switzerland) · 2016Review
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13 authors.
Funding
Abstract
Streptococcus suis is a major porcine and zoonotic pathogen responsible for significant economic losses in the pig industry and an increasing number of human cases. Multiple isolates of S. suis show marked genomic diversity. Here, we report the analysis of whole genome sequences of nine pig isolates that caused disease typical of S. suis and had phenotypic characteristics of S. suis, but their genomes were divergent from those of many other S. suis isolates. Comparison of protein sequences predicted from divergent genomes with those from normal S. suis reduced the size of core genome from 793 to only 397 genes. Divergence was clear if phylogenetic analysis was performed on reduced core genes and MLST alleles. Phylogenies based on certain other genes (16S rRNA, sodA, recN, and cpn60) did not show divergence for all isolates, suggesting recombination between some divergent isolates with normal S. suis for these genes. Indeed, there is evidence of recent recombination between the divergent and normal S. suis genomes for 249 of 397 core genes. In addition, phylogenetic analysis based on the 16S rRNA gene and 132 genes that were conserved between the divergent isolates and representatives of the broader Streptococcus genus showed that divergent isolates were more closely related to S. suis. Six out of nine divergent isolates possessed a S. suis-like capsule region with variation in capsular gene sequences but the remaining three did not have a discrete capsule locus. The majority (40/70), of virulence-associated genes in normal S. suis were present in the divergent genomes. Overall, the divergent isolates extend the current diversity of S. suis species but the phenotypic similarities and the large amount of gene exchange with normal S. suis gives insufficient evidence to assign these isolates to a new species or subspecies. Further, sampling and whole genome analysis of more isolates is warranted to understand the diversity of the species.
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