ArticleNucleic acids research2016
The quorum-sensing regulator ComA from Bacillus subtilis activates transcription using topologically distinct DNA motifs.
Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Bibliometric analysis and visualization of quorum sensing research over the last two decade.Frontiers in microbiology · 2024Pooled it
- Humic acid's sheltering effect paradoxically promotes antibiotic resistance gene dissemination during peroxymonosulfate water treatment.Nature communications · 2026Article
- Controlled interkingdom cell-cell communication betweenFrontiers in microbiology · 2024Article
- A review on surfactin: molecular regulation of biosynthesis.Archives of microbiology · 2023Review
- Structural basis of direct and inverted DNA sequence repeat recognition by helix-turn-helix transcription factors.Nucleic acids research · 2022Article
- Review
- Comparative Genome Analysis of TwoGenes · 2022Article
- Resolving the conflict between antibiotic production and rapid growth by recognition of peptidoglycan of susceptible competitors.Nature communications · 2022Article
- Surfactin Stimulated by Pectin Molecular Patterns and Root Exudates Acts as a Key Driver of themBio · 2021Article
- Maltose effective improving production and regulatory biosynthesis of plantaricin EF in Lactobacillus plantarum 163.Applied microbiology and biotechnology · 2021Article
- Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis.Communications biology · 2021Article
- Multiple Layered Control of the Conjugation Process of theFrontiers in molecular biosciences · 2021Review
- Fungal-bacterial interaction selects for quorum sensing mutants with increased production of natural antifungal compounds.Communications biology · 2020Article
- Reversible regulation of conjugation of Bacillus subtilis plasmid pLS20 by the quorum sensing peptide responsive anti-repressor RappLS20.Nucleic acids research · 2020Article
- The ComX Quorum Sensing Peptide ofMicroorganisms · 2020Article
- Ratiometric population sensing by a pump-probe signaling system in Bacillus subtilis.Nature communications · 2020Article
- Synergistic Degradation of Pyrethroids by the Quorum Sensing-Regulated Carboxylesterase ofFrontiers in bioengineering and biotechnology · 2020Article
- Genetic Screening and Expression Analysis of PsychrophilicMicroorganisms · 2019Article
- Social behaviours by Bacillus subtilis: quorum sensing, kin discrimination and beyond.Molecular microbiology · 2018Review
- [Blepharitis component of dry eye syndrome].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ComA-like transcription factors regulate the quorum response in numerous Gram-positive bacteria. ComA proteins belong to the tetrahelical helix-turn-helix superfamily of transcriptional activators, which bind as homodimers to inverted sequence repeats in the DNA. Here, we report that ComA from Bacillus subtilis recognizes a topologically distinct motif, in which the binding elements form a direct repeat. We provide in vitro and in vivo evidence that the canonical and non-canonical site play an important role in facilitating type I and type II promoter activation, respectively, by interacting with different subunits of RNA polymerase. We furthermore show that there is a variety of contexts in which the non-canonical site can occur and identify new direct target genes that are located within the integrative and conjugative element ICEBs1. We therefore suggest that ComA acts as a multifunctional transcriptional activator and provides a striking example for complexity in protein-DNA interactions that evolved in the context of quorum sensing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.