Trial reportEuropean journal of nutrition2017
Efficacy and safety of a natural mineral water rich in magnesium and sulphate for bowel function: a double-blind, randomized, placebo-controlled study.
Trial report in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04130620 (Red Blood Cell Validation of Magnesium Deficiency as Determined by a Muscle Stretch Test), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Red Blood Cell Validation of Magnesium Deficiency as Determined by a Muscle Stretch Test
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Natural Mineral Water and Diuresis: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Effects of drinking natural hydrogen sulfide (HInternational journal of biometeorology · 2020Pooled it
- Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial.Neurogastroenterology and motility · 2026Trial
- Daily consumption of sulfate- and magnesium-rich mineral water enhances bowel function in adults with chronic constipation: a randomized double-blind real-world trial.Frontiers in nutrition · 2026Trial
- Trial
- Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.World journal of pediatrics : WJP · 2021Trial
- Trial
- Comparison of the Effectiveness of Three Different Combinations for Colonoscopy Preparation: A Multicenter Randomized Clinical Trial.Diagnostics (Basel, Switzerland) · 2026Article
- Dietary strategies for chronic constipation: smartly targeting hormonal and reflex pathways for optimal recovery.Frontiers in pharmacology · 2026Review
- Review
- Beyond Thirst: Influence of Bicarbonate Mineral Water on Cardiovascular Risk Factors, Gastrointestinal Function, and Liver Health.Food science & nutrition · 2025Review
- Defecation after magnesium supplementation enhances cognitive performance in triathletes.Sports medicine and health science · 2025Article
- Managing diverticula: dietary changes for a more comfortable life.Przeglad gastroenterologiczny · 2025Article
- Marked Reduction of Oxidant Species after Sulfureous Crenotherapy in Females with Joint Diseases and Psoriasis: A Retrospective Real-Life Study.Journal of clinical medicine · 2023Article
- Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future.Journal of clinical medicine · 2023Review
- Gut microbiota and cognitive development in infant mice: Quantity and source of potable water.PloS one · 2023Article
- Effect of Calcium-Sulphate-Bicarbonate Water in a Murine Model of Non-Alcoholic Fatty Liver Disease: A Histopathology Study.International journal of molecular sciences · 2022Article
- Saudi Experts Consensus on Diagnosis and Management of Pediatric Functional Constipation.Pediatric gastroenterology, hepatology & nutrition · 2022Review
- Review
- Benefits of crenotherapy in digestive tract pathology (Review).Experimental and therapeutic medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe present placebo-controlled, double-blind, randomized trial aimed to investigate whether a natural mineral water rich in magnesium sulphate and sodium sulphate (Donat Mg) may help to improve bowel function.
methodsA total of 106 otherwise healthy subjects with functional constipation were randomly assigned to consume 300 or 500 mL of a natural mineral water as compared to placebo water, over a course of 6 weeks. The 300-mL arms were terminated due to the results of a planned interim analysis. Subjects documented the complete spontaneous bowel movements, spontaneous and overall bowel movements/week, stool consistency, gastrointestinal symptoms and general well-being in a diary. Change in the number of complete spontaneous bowel movements was defined as the primary outcome.
resultsFor the 75 subjects in the 500-mL arms, the change in the number of complete spontaneous bowel movements per week tended to be higher in the active group when compared to placebo after 6 weeks (T2 = 1.8; p
conclusionsThe daily consumption of a natural mineral water rich in magnesium sulphate and sodium sulphate improved bowel movement frequency and stool consistency in subjects with functional constipation. Moreover, the subjects' health-related quality of life improved. CLINICAL
trial registrationEudraCT No 2012-005130-11.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.