SynthesisScientific reports2015
Body mass index and risk of lung cancer: Systematic review and dose-response meta-analysis.
Synthesis in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03654105 (Multifactorial Intervention of Primary Prevention in High Risk Subjects), which is not on this map. Cited by 59 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multifactorial Intervention of Primary Prevention in High Risk Subjects: a Randomized Trial
Who cites it
59 citing papers in PubMed, 6 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Association between metabolically healthy obesity and metastasis in lung cancer patients - a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Tobacco Smoking and Risk of Second Primary Lung Cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2021Pooled it
- Tea consumption and colorectal cancer risk: a meta-analysis of prospective cohort studies.European journal of nutrition · 2020Pooled it
- Pooled it
- Body mass index and mortality in lung cancer patients: a systematic review and meta-analysis.European journal of clinical nutrition · 2018Pooled it
- Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies.Nutrients · 2016Pooled it
- Racial difference in BMI and lung cancer diagnosis: analysis of the National Lung Screening Trial.BMC cancer · 2022Trial
- Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study.BMC medicine · 2022Trial
- A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study.EBioMedicine · 2018Trial
- The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study.Scientific reports · 2016Trial
- Bioelectrical impedance-derived body composition and systemic therapy outcomes in non-small cell lung cancer.Translational lung cancer research · 2026Article
- Healthy lifestyle and cancer risk: a pan-cancer analysis in the UK Biobank prospective cohort.British journal of cancer · 2026Article
- Genome-wide DNA methylation profiling reveals body mass Index-dependent epigenetic signatures associated with lung cancer susceptibility.BMC cancer · 2026Article
- Association between body-mass index change and lung cancer risk in Korea: nested case-control study.BMC cancer · 2025Observational
- Metabolome-Wide Mendelian Randomization Identifies Maleate as a Mediator of the Effect of Obesity on the Risk of Small Cell Lung Cancer.Food science & nutrition · 2025Article
- Sex-Specific Associations of Total Bilirubin, ALBI, and PALBI with Lung Cancer Risk: Interactions with Smoking and Alcohol.Healthcare (Basel, Switzerland) · 2025Article
- Clinical Validation of Plasma Metabolite Markers for Early Lung Cancer Detection.International journal of molecular sciences · 2025Article
- The Impact of Nutritional Support on Outcomes of Lung Cancer Surgery-Narrative Review.Journal of clinical medicine · 2025Review
- Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018.Journal of epidemiology and global health · 2025Article
- Survival assessment and pre-diagnostic risk factors for lung cancer incidence: Insights from the Golestan Cohort Study.PloS one · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Questions remain about the significance of the dose-response relationship between body mass index (BMI) and lung cancer (LC) risk. Pertinent studies were identified through a search in EMBASE and PUBMED from July 2014 until March 2015. The summary relative risk (SRR) and confidence interval (CI) were estimated. The dose-response relationship was assessed using a restricted cubic spline. The overall meta-analysis showed evidence of a nonlinear association between BMI and LC risk (Pnonlinearity < 0.001). The SRR were 0.98 (95%CI: 0.95-1.01) for 25 kg/m(2), 0.91 (95%CI: 0.85-0.98) for 30 kg/m(2) and 0.81 (95% CI: 0.72-0.91) for 35 kg/m(2), with mild between-study heterogeneity (I(2) = 5%). The results of the stratified analysis by gender were comparable to those of the overall meta-analysis. When stratified by smoking status, linear dose-response associations were observed for current smokers, ex-smokers and non-smokers (Pnonlinearity > 0.05), whereas the effects were attenuated when restricting analysis to non-smokers, and at the point of 30 kg/m(2), the SRR was 0.96 (95%CI: 0.86-1.07) for males and 0.95 (95%CI: 0.89-1.02) for females. This meta-analysis provides quantitative evidence that increasing BMI is a protective factor against LC. Keeping normal-to-moderate BMI should be prescribed as an evidence-based lifestyle tip for LC prevention in smokers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.