Evidence map›Paper›PMID 26582402›Full record

ArticleJournal of the American Society of Nephrology : JASN2016

International Comparisons to Assess Effects of Payment and Regulatory Changes in the United States on Anemia Practice in Patients on Hemodialysis: The Dialysis Outcomes and Practice Patterns Study.

Douglas S Fuller, Brian A Bieber, Ronald L Pisoni, Yun Li, Hal Morgenstern, Tadao Akizawa, Stefan H Jacobson, Francesco Locatelli, Friedrich K Port, Bruce M Robinson

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Association Between Implementation Of Novel Therapies And Improved Survival In Patients Starting Hemodialysis: The Swedish Renal Registry 2006-2015.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Article
  7. Review
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Iron Therapy Challenges for the Treatment of Nondialysis CKD Patients.Clinical journal of the American Society of Nephrology : CJASN · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Douglas S FullerArbor Research Collaborative for Health, Ann Arbor, Michigan; Doug.Fuller@ArborResearch.org.
Brian A BieberArbor Research Collaborative for Health, Ann Arbor, Michigan;
Ronald L PisoniArbor Research Collaborative for Health, Ann Arbor, Michigan;
Yun LiDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan;
Hal MorgensternDepartments of Epidemiology and Environmental Health Sciences, School of Public Health, Department of Urology, Medical School, University of Michigan, Ann Arbor, Michigan;
Tadao AkizawaDepartment of Nephrology, Showa University School of Medicine, Shinagawa, Tokyo, Japan;
Stefan H JacobsonDepartment of Clinical Sciences, Division of Nephrology, Danderyd University Hospital, Stockholm, Sweden; and.
Francesco LocatelliDepartment of Nephrology, Ospedale A. Manzoni, Lecco, Italy.
Friedrich K PortArbor Research Collaborative for Health, Ann Arbor, Michigan;
Bruce M RobinsonArbor Research Collaborative for Health, Ann Arbor, Michigan; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For years, erythropoiesis-stimulating agent (ESA) use among patients on dialysis was much higher in the United States than in Europe or Japan. Sweeping changes to dialysis reimbursement and regulatory policies for ESA in the United States in 2011 were expected to reduce ESA use and hemoglobin levels. We used the Dialysis Outcomes and Practice Patterns Study (DOPPS) data from 7129 patients in 223 in-center hemodialysis facilities (average per month) to estimate and compare time trends in ESA dose and hemoglobin levels among patients on hemodialysis in the United States, Germany, Italy, Spain, the United Kingdom, and Japan. From 2010 to 2013, substantial declines in ESA use and hemoglobin levels occurred in the United States but not in other DOPPS countries. Between August of 2010 and April of 2013, mean weekly ESA dose in the United States decreased 40.4% for black patients and 38.0% for nonblack patients; mean hemoglobin decreased from 11.5 g/dl in black patients and 11.4 g/dl in nonblack patients to 10.6 g/dl in both groups. In 2010 and 2013, adjusted weekly ESA doses per kilogram were 41% and 11% lower, respectively, in patients in Europe and 60% and 18% lower, respectively, in patients in Japan than in nonblack patients in the United States. Adjusted hemoglobin levels in 2010 and 2013 were 0.07 g/dl lower and 0.56 g/dl higher, respectively, in patients in Europe and 0.93 and 0.01 g/dl lower, respectively, in patients in Japan than in nonblack patients in the United States. In conclusion, ESA dosing reductions in the United States likely reflect efforts in response to changes in reimbursement policy and regulatory guidance.

Indexed as

Practice Patterns, Physicians'Reimbursement MechanismsRenal DialysisAgedAnemiaEuropeFemaleHematinicsHumansJapanMaleMiddle AgedOutcome Assessment, Health CareUnited StatesHematinicsanemiaepoetinerythropoietinESRDhemodialysis

Identifiers

PMID26582402
PMCPMC4926983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.