Observational studyCancer research and treatment2016
Effect of Helicobacter pylori Eradication on Long-Term Survival after Distal Gastrectomy for Gastric Cancer.
Observational study in Cancer research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The relationship between the eradication of Helicobacter pylori and the occurrence of stomach cancer: an updated meta-analysis and systemic review.BMC gastroenterology · 2025Pooled it
- Positive H. pylori status predicts better prognosis of non-cardiac gastric cancer patients: results from cohort study and meta-analysis.BMC cancer · 2022Pooled it
- Follow-Up and Strategies After Curative Surgical Resection for Gastric Cancer.The Korean journal of helicobacter and upper gastrointestinal research · 2025Review
- Prognostic factors in gastric cancer survivors comparing Cox proportional hazards and machine learning using a Korean National cohort.Discover oncology · 2025Article
- Changes in Helicobacter pylori Status in Patients Who Underwent Partial Gastrectomy for Gastric Cancer Therapy.The Korean journal of helicobacter and upper gastrointestinal research · 2025Article
- Relationship betweenWorld journal of clinical oncology · 2025Article
- The influence ofFrontiers in immunology · 2025Article
- Anti-Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy.JAMA network open · 2024Article
- Risk factors for remnant gastric cancer after distal gastrectomy for gastric cancer: a retrospective database review.Journal of gastrointestinal oncology · 2023Article
- The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single-center prospective study.Cancer reports (Hoboken, N.J.) · 2023Article
- Article
- Helicobacter Pylori and Gastric Cancer Progression.Current microbiology · 2022Review
- Current Evidence for a Paradigm Shift in Gastric Cancer Prevention From Endoscopic Screening toJournal of gastric cancer · 2022Review
- Effect of gastric cancer screening on long-term survival of gastric cancer patients: results of Korean national cancer screening program.Journal of gastroenterology · 2022Article
- Antibiotic Resistance of Helicobacter pylori Isolated from Patients after Partial Gastrectomy: A Retrospective Study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- T stage and venous invasion are crucial prognostic factors for long-term survival of patients with remnant gastric cancer: a cohort study.World journal of surgical oncology · 2021Article
- Effect of Helicobacter pylori eradication after subtotal gastrectomy on the survival rate of patients with gastric cancer: follow-up for up to 15 years.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- Review
- Do We Need to Retest ofGut and liver · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNegative Helicobacter pylori status has been identified as a poor prognostic factor for survival in gastric cancer (GC) patients who underwent surgery. The aim of this study was to examine the effect of H. pylori eradication on long-term outcomes after distal gastrectomy for GC. MATERIALS AND
methodsWe analyzed the survival of 169 distal GC patients enrolled in a prospective randomized trial evaluating histologic changes of gastric mucosa after H. pylori eradication in the remnant stomach. The outcomes measured were overall survival (OS) and GC recurrence rates.
resultsThe median follow-up duration was 9.4 years. In the modified intention-to-treat analysis including patients who underwent H. pylori treatment (n=87) or placebo (n=82), 5-year OS rates were 98.9% in the treatment group and 91.5% in the placebo group, and Kaplan-Meier analysis showed no significant difference in OS (p=0.957) between groups. In multivariate analysis, no difference in overall mortality was observed between groups (adjusted hazard ratio [aHR] for H. pylori treatment, 0.75; p=0.495) or H. pylori-eradicated status (aHR for positive H. pylori status, 1.16; p=0.715), while old age, male sex, and advanced stage ≥ IIIa were independent risk factors. Six patients in the treatment group (6.9%) and seven patients in the placebo group (8.5%) had GC recurrences, and GC recurrence rates were not different according to H. pylori treatment (5-year GC recurrence rates, 4.6% in the treatment group vs. 8.5% in the placebo group; p=0.652).
conclusionH. pylori eradication for GC patients who underwent distal gastrectomy did not compromise long-term survival after surgery.
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