ReviewJournal of industrial microbiology & biotechnology2016
Natural product derived insecticides: discovery and development of spinetoram.
Review in Journal of industrial microbiology & biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Knockout of nAChR subunits in spider mites and their phytoseiid predators confers spinosyn cross-resistance and reveals a conserved mode of action in mites.Insect biochemistry and molecular biology · 2026Article
- Microbial unusual gene clusters without prominent core enzymes: natural products, biosynthesis and genome mining.The Journal of antibiotics · 2026Review
- Toxicity and Residual Effect of Toxic Baits on Adults ofInsects · 2026Article
- Article
- Article
- Spinetoram-Induced Potential Neurotoxicity through Autophagy Mediated by Mitochondrial Damage.Molecules (Basel, Switzerland) · 2024Article
- Biological Activity of Hybrid Molecules Based on Major Constituents ofLife (Basel, Switzerland) · 2023Article
- A tale of two metrics: the EPA Risk Quotient Approach versus the delay in Population Growth Index for determination of pesticide risk to aquatic species.Ecotoxicology (London, England) · 2021Article
- RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters.Nucleic acids research · 2020Article
- Acetogenin-Based Formulated Bioinsecticides on Anastrepha fraterculus: Toxicity and Potential Use in Insecticidal Toxic Baits.Neotropical entomology · 2020Article
- Compatibility of pesticides used in strawberry crops with predatory mites Stratiolaelaps scimitus (Womersley) and Cosmolaelaps brevistilis (Karg).Ecotoxicology (London, England) · 2020Article
- Side effects of toxic bait formulations on Diachasmimorpha longicaudata (Hymenoptera: Braconidae).Scientific reports · 2019Article
- Bacteriophage-resistant industrial fermentation strains: from the cradle to CRISPR/Cas9.Journal of industrial microbiology & biotechnology · 2018Review
- Gifted microbes for genome mining and natural product discovery.Journal of industrial microbiology & biotechnology · 2017Review
- Oxidative Cyclization in Natural Product Biosynthesis.Chemical reviews · 2017Review
- A New Medium for Improving Spinosad Production by Saccharopolyspora spinosa.Jundishapur journal of microbiology · 2016Article
- Natural product discovery: past, present, and future.Journal of industrial microbiology & biotechnology · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review highlights the importance of natural product research and industrial microbiology for product development in the agricultural industry, based on examples from Dow AgroSciences. It provides an overview of the discovery and development of spinetoram, a semisynthetic insecticide derived by a combination of a genetic block in a specific O-methylation of the rhamnose moiety of spinosad coupled with neural network-based QSAR and synthetic chemistry. It also emphasizes the key role that new technologies and multidisciplinary approaches play in the development of current spinetoram production strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.