Trial reportAddiction (Abingdon, England)2016
Identifying effective intervention components for smoking cessation: a factorial screening experiment.
Trial report in Addiction (Abingdon, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Opt-IN: Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity
Physical Activity in Adolescents With Chronic Kidney Disease
Who cites it
59 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Korean Clinical Practice Guideline of Korean Society for Research on Nicotine and Tobacco (KSRNT) and National Evidence-based Healthcare Collaborating Agency (NECA) on Treatment of Tobacco Use 2024.Journal of Korean medical science · 2025Guideline
- Differences in the effectiveness of individual-level smoking cessation interventions by socioeconomic status.The Cochrane database of systematic reviews · 2025Pooled it
- Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation.The Cochrane database of systematic reviews · 2023Pooled it
- Strategies to improve smoking cessation rates in primary care.The Cochrane database of systematic reviews · 2021Pooled it
- Telephone counselling for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- Nicotine replacement therapy versus control for smoking cessation.The Cochrane database of systematic reviews · 2018Pooled it
- Mobile Health Technology for Personalized Tobacco Cessation Support in Laos (Project Support Laos): Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Trial
- Multiple Pharmacotherapy Adaptations for Smoking Cessation Based on Treatment Response in Black Adults Who Smoke: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Successful Optimization of Tobacco Dependence Treatment in the Emergency Department: A Randomized Controlled Trial Using the Multiphase Optimization Strategy.Annals of emergency medicine · 2023Trial
- Effectiveness of a Dyadic Buddy App for Smoking Cessation: Randomized Controlled Trial.Journal of medical Internet research · 2021Trial
- Time-varying effects of 'optimized smoking treatment' on craving, negative affect and anhedonia.Addiction (Abingdon, England) · 2021Trial
- Predictors of adherence to nicotine replacement therapy: Machine learning evidence that perceived need predicts medication use.Drug and alcohol dependence · 2019Trial
- A Randomized Controlled Trial of an Optimized Smoking Treatment Delivered in Primary Care.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Trial
- Extended treatment for cigarette smoking cessation: a randomized control trial.Addiction (Abingdon, England) · 2017Trial
- Toward precision smoking cessation treatment I: Moderator results from a factorial experiment.Drug and alcohol dependence · 2017Trial
- Toward precision smoking cessation treatment II: Proximal effects of smoking cessation intervention components on putative mechanisms of action.Drug and alcohol dependence · 2017Trial
- Application of the multiphase optimization strategy to a pilot study: an empirical example targeting obesity among children of low-income mothers.BMC public health · 2016Trial
- Trial
- Comparative effectiveness of intervention components for producing long-term abstinence from smoking: a factorial screening experiment.Addiction (Abingdon, England) · 2016Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
aimsTo identify promising intervention components intended to help smokers to attain and maintain abstinence in their quit smoking attempts.
designA fully crossed, six-factor randomized fractional factorial experiment.
settingEleven primary care clinics in southern Wisconsin, USA.
participantsA total of 637 adult smokers (55% women, 88% white) motivated to quit smoking who visited primary care clinics.
interventionsSix intervention components designed to prepare smokers to quit, and achieve and maintain abstinence (i.e. for the preparation, cessation and maintenance phases of smoking treatment): (1) preparation nicotine patch versus none; (2) preparation nicotine gum versus none; (3) preparation counseling versus none; (4) intensive cessation in-person counseling versus minimal; (5) intensive cessation telephone counseling versus minimal; and (6) 16 versus 8 weeks of combination nicotine replacement therapy (nicotine patch + nicotine gum). MEASUREMENTS: Seven-day self-reported point-prevalence abstinence at 16 weeks.
findingsPreparation counseling significantly improved week 16 abstinence rates (P = .04), while both forms of preparation nicotine replacement therapy interacted synergistically with intensive cessation in-person counseling (P < 0.05). Conversely, intensive cessation phone counseling and intensive cessation in-person counseling interacted antagonistically (P < 0.05)-these components produced higher abstinence rates by themselves than in combination.
conclusionsPreparation counseling and the combination of intensive cessation in-person counseling with preparation nicotine gum or patch are promising intervention components for smoking and should be evaluated as an integrated treatment package.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.