ArticleExperimental biology and medicine (Maywood, N.J.)2016
Cardioprotective effects of lysyl oxidase inhibition against volume overload-induced extracellular matrix remodeling.
Article in Experimental biology and medicine (Maywood, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Composition and Influence of Fibrogenic Niche in Myocardial Fibrosis.Reviews in cardiovascular medicine · 2026Review
- Buyang Huanwu Decoction Alleviates Chronic Intermittent Hypoxia-Induced Myocardial Inflammation and Fibrosis via the NF-Human mutation · 2026Article
- Single-cell analysis reveals lysyl oxidase (Lox)Journal of advanced research · 2023Article
- Anti-Fibrotic Potential of Angiotensin (1-7) in Hemodynamically Overloaded Rat Heart.International journal of molecular sciences · 2023Article
- Article
- Matricellular Protein Cilp1 Promotes Myocardial Fibrosis in Response to Myocardial Infarction.Circulation research · 2021Article
- Dimethyl fumarate preserves left ventricular infarct integrity following myocardial infarction via modulation of cardiac macrophage and fibroblast oxidative metabolism.Journal of molecular and cellular cardiology · 2021Article
- Cardiac fibrosis.Cardiovascular research · 2021Review
- Cross your heart? Collagen cross-links in cardiac health and disease.Cellular signalling · 2021Review
- Review
- Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes.Matrix biology : journal of the International Society for Matrix Biology · 2019Review
- Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis.Nature communications · 2018Article
- Inhibitor of lysyl oxidase improves cardiac function and the collagen/MMP profile in response to volume overload.American journal of physiology. Heart and circulatory physiology · 2018Article
- A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure.American journal of physiology. Heart and circulatory physiology · 2018Article
- Chronic Ethanol Administration Prevents Compensatory Cardiac Hypertrophy in Pressure Overload.Alcoholism, clinical and experimental research · 2018Article
- Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload.Journal of molecular and cellular cardiology · 2018Article
- Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2018Article
- Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans.Basic research in cardiology · 2018Article
- Estrogen receptor antagonism exacerbates cardiac structural and functional remodeling in female rats.American journal of physiology. Heart and circulatory physiology · 2017Article
- Exposure to chronic alcohol accelerates development of wall stress and eccentric remodeling in rats with volume overload.Journal of molecular and cellular cardiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A hallmark of heart failure (HF) is adverse extracellular matrix (ECM) remodeling, which is regulated by the collagen cross-linking enzyme, lysyl oxidase (LOX). In this study, we evaluate the efficacy of LOX inhibition to prevent adverse left ventricular (LV) remodeling and dysfunction using an experimental model of HF. Sprague-Dawley rats were subjected to surgically induced volume overload (VO) by creation of aortocaval fistula (ACF). A LOX inhibitor, beta-aminopropionitrile (BAPN; 100 mg/kg/day), was administered to rats with ACF or sham surgery at eight weeks postsurgery. Echocardiography was used to assess progressive alterations in cardiac ventricular structure and function. Left ventricular (LV) catheterization was used to assess alterations in contractility, stiffness, LV pressure and volume, and other indices of cardiac function. The LV ECM alterations were assessed by: (a) histological staining of collagen, (b) protein expression of collagen types I and III, (c) hydroxyproline assay, and (d) cross-linking assay. LOX inhibition attenuated VO-induced increases in cardiac stress, and attenuated increases in interstitial myocardial collagen, total collagen, and protein levels of collagens I and III. Both echocardiography and catheterization measurements indicated improved cardiac function post-VO in BAPN treated rats vs. untreated. Inhibition of LOX attenuated VO-induced decreases in LV stiffness and cardiac function. Overall, our data indicate that LOX inhibition was cardioprotective in the volume overloaded heart.
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Registered trials
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