ArticleProceedings. Biological sciences2015
Health trajectories reveal the dynamic contributions of host genetic resistance and tolerance to infection outcome.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Co-infection with a viral pathogen (Theiler's murine encephalomyelitis virus) tended to improve host tolerance but significantly enhanced resistance to Heligmosomoides bakeri.Veterinary research communications · 2026Article
- Distinct host-pathogen and microbiome responses of aoudad (Ammotragus lervia) and bighorn sheep (Ovis canadensis) following exposure to Mycoplasma ovipneumoniae with or without co-exposure to leukotoxigenic Pasteurellaceae.BMC veterinary research · 2026Article
- Getting to grips with resilience: Toward large-scale phenotyping of this complex trait.JDS communications · 2024Article
- The cost of host genetic resistance on body condition: Evidence from divergently selected sheep.Evolutionary applications · 2022Article
- Elucidating Mechanisms of Tolerance tomBio · 2022Article
- Breeding for disease resilience: opportunities to manage polymicrobial challenge and improve commercial performance in the pig industry.CABI agriculture and bioscience · 2022Review
- Potential of genomic technologies to improve disease resistance in molluscan aquaculture.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- A novel modelling approach to quantify the response of dairy goats to a high-concentrate diet.Scientific reports · 2020Article
- Why breed disease-resilient livestock, and how?Genetics, selection, evolution : GSE · 2020Review
- Transmissible Cancers in an Evolutionary Perspective.iScience · 2020Review
- The evolution of resistance and tolerance as cancer defences.Parasitology · 2020Article
- Harnessing longitudinal information to identify genetic variation in tolerance of pigs to Porcine Reproductive and Respiratory Syndrome virus infection.Genetics, selection, evolution : GSE · 2018Article
- Does selection for growth rate in broilers affect their resistance and tolerance to Eimeria maxima?Veterinary parasitology · 2018Article
- Novel Resilience Phenotypes Using Feed Intake Data From a Natural Disease Challenge Model in Wean-to-Finish Pigs.Frontiers in genetics · 2018Article
- Article
- Use of multi-trait and random regression models to identify genetic variation in tolerance to porcine reproductive and respiratory syndrome virus.Genetics, selection, evolution : GSE · 2017Article
- Treatable traits and therapeutic targets: Goals for systems biology in infectious disease.Current opinion in systems biology · 2017Review
- EMA and EFSA Joint Scientific Opinion on measures to reduce the need to use antimicrobial agents in animal husbandry in the European Union, and the resulting impacts on food safety (RONAFA).EFSA journal. European Food Safety Authority · 2017Article
- The effect of diet and time after bacterial infection on fecundity, resistance, and tolerance in Drosophila melanogaster.Ecology and evolution · 2016Article
- Beyond killing: Can we find new ways to manage infection?Evolution, medicine, and public health · 2016Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Resistance and tolerance are two alternative strategies hosts can adopt to survive infections. Both strategies may be genetically controlled. To date, the relative contribution of resistance and tolerance to infection outcome is poorly understood. Here, we use a bioluminescent Listeria monocytogenes (Lm) infection challenge model to study the genetic determination and dynamic contributions of host resistance and tolerance to listeriosis in four genetically diverse mouse strains. Using conventional statistical analyses, we detect significant genetic variation in both resistance and tolerance, but cannot capture the time-dependent relative importance of either host strategy. We overcome these limitations through the development of novel statistical tools to analyse individual infection trajectories portraying simultaneous changes in infection severity and health. Based on these tools, early expression of resistance followed by expression of tolerance emerge as important hallmarks for surviving Lm infections. Our trajectory analysis further reveals that survivors and non-survivors follow distinct infection paths (which are also genetically determined) and provides new survival thresholds as objective endpoints in infection experiments. Future studies may use trajectories as novel traits for mapping and identifying genes that control infection dynamics and outcome. A Matlab script for user-friendly trajectory analysis is provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.