Evidence map›Paper›PMID 26581898›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016

Chemotherapy-induced gut toxicity and pain: involvement of TLRs.

Rachel J Gibson, Janet K Coller, Hannah R Wardill, Mark R Hutchinson, Scott Smid, Joanne M Bowen

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Chemotherapy induced gastrointestinal toxicities.Advances in cancer research · 2022
    Review
  5. Review
  6. Observational
  7. Review
  8. Article
  9. From the Bottom-Up: Chemotherapy and Gut-Brain Axis Dysregulation.Frontiers in behavioral neuroscience · 2018
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rachel J GibsonDiscipline of Anatomy and Pathology, School of Medicine, University of Adelaide, North Terrace, Adelaide, 5005, South Australia, Australia. rachel.gibson@adelaide.edu.au.
Janet K CollerDiscipline of Pharmacology, School of Medicine, University of Adelaide, Adelaide, Australia.
Hannah R WardillDiscipline of Anatomy and Pathology, School of Medicine, University of Adelaide, North Terrace, Adelaide, 5005, South Australia, Australia.
Mark R HutchinsonDiscipline of Physiology, School of Medicine, University of Adelaide, Adelaide, Australia.
Scott SmidDiscipline of Pharmacology, School of Medicine, University of Adelaide, Adelaide, Australia.
Joanne M BowenDiscipline of Physiology, School of Medicine, University of Adelaide, Adelaide, Australia.
University of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChemotherapy-induced gut toxicity is associated with significant pain, and pain influences gut function. Toll-like receptors (TLRs) that regulate gut homeostasis are activated by tissue damage and microbes, and their altered expression following chemotherapy may change cellular responses. This study examined the interaction between chemotherapy-induced gut toxicity and pain and related these to gut TLR and glial fibrillary acidic protein (GFAP) expression.

methodsFemale tumor bearing Dark Agouti rats received irinotecan (175 mg/kg, n = 34) or vehicle (n = 5) and were assessed over 120 h for gut toxicity (diarrhea, weight loss), pain (facial), and GFAP, TLR2, 4, 5, and 9 gut expression.

resultsIrinotecan caused diarrhea (72 % of animals grade ≥ 1), weight loss (11.1 ± 6.6 %, P < 0.0001), and pain (5 (0-5), P < 0.0001) all peaking at 72 h. Higher pain scores were observed in rats with diarrhea versus those without: median (range) of 2.0 (0-5) versus 0 (0-5), P = 0.01. Irinotecan also caused a decrease in TLR4 and 5, and an increase in GFAP expression in jejuna crypt at 96 and 120 h (all P < 0.05); with lower TLR4 expression associated with lower pain (P = 0.012).

conclusionsThe association between gut toxicity and pain suggests these toxicities are linked, possibly via TLR-mediated inflammatory pathways. Further, as TLR4 and 5 expression was absent during recovery in the jejuna and GFAP expression was increased in the jejuna, this implies expression of these may be critical in the healing phase following chemotherapy. Detailed studies of gut TLRs and GFAP are now warranted.

Indexed as

Agouti Signaling ProteinAnimalsFemaleGastrointestinal DiseasesRatsToll-Like ReceptorsAgouti Signaling ProteinAsip protein, ratToll-Like ReceptorsChemotherapyGFAPGut toxicityPainTLR

Identifiers

PMID26581898
OpenAlexW2173587820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.