ArticleEuropean journal of clinical pharmacology2016
Gender differences in statin prescription rates, adequacy of dosing, and association of statin therapy with outcome after heart failure hospitalization: a retrospective analysis in a community setting.
Article in European journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association is not causation: treatment effects cannot be estimated from observational data in heart failure.European heart journal · 2018Pooled it
- Gender Disparities in Statin Prescriptions in People With HIV With Low/Moderate to High Cardiovascular Risk.Open forum infectious diseases · 2024Article
- Gender inequalities in secondary prevention of cardiovascular disease: a scoping review.International journal for equity in health · 2024Article
- Retrospective real-world analysis of adherence and persistence to lipid-lowering therapy in Germany.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Italian Association of Hospital Cardiologists Position Paper 'Gender discrepancy: time to implement gender-based clinical management'.European heart journal supplements : journal of the European Society of Cardiology · 2024Article
- Statin-induced Liver Injury Patterns: A Clinical Review.Journal of clinical and translational hepatology · 2022Review
- Gender Differences in the Diagnosis of Dyslipidemia: ESCARVAL-GENERO.International journal of environmental research and public health · 2021Article
- The Person's Care Requires a Sex and Gender Approach.Journal of clinical medicine · 2021Review
- Utilization of statins and LDL-cholesterol target attainment in Turkish patients with type 2 diabetes - a nationwide cross-sectional study (TEMD dyslipidemia study).Lipids in health and disease · 2020Article
- Medication use among older people in Europe: Implications for regulatory assessment and co-prescription of new medicines.British journal of clinical pharmacology · 2020Article
- Interventions to Improve Adherence to Cardiovascular Medication: What About Gender Differences? A Systematic Literature Review.Patient preference and adherence · 2020Review
- Vulnerabilities to Health Disparities and Statin Use in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study.Journal of the American Heart Association · 2017Article
- Statin-induced myopathy in a usual care setting-a prospective observational study of gender differences.European journal of clinical pharmacology · 2016Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe existence of gender differences in the management of statin therapy among patients with chronic heart failure (HF) is still poorly investigated. We aimed at exploring the effect of gender on statin prescription rates and adequacy of dosing and on the association between statin therapy and all-cause 1-year mortality, after HF hospitalization in a community setting.
methodsStatin prescription rates, adequacy of dosing (estimated as a PDD/DDD ratio >0.80), and 1-year mortality were retrospectively assessed in 2088 consecutive patients discharged from 5 local community hospitals with a definite diagnosis of HF after a mean length of stay of 7.6 days. The effect of gender was explored using multivariable logistic and Cox analyses adjusting to confounders.
resultsWomen showed a lower statin prescription rate (25.7 vs 35.3%, P < 0.0001) and a lower prevalence of adequate statin dose (32.6 vs 42.3%, P < 0.0001) than men. Female gender was independently associated with a 24% lower probability of statin prescription and a 48% higher probability of inadequate statin dose. Statin prescription and adequacy of dosing were associated with 35 and 44% decreases in the risk of 1-year mortality, respectively, irrespective of gender. A nested case/control analysis confirmed that adequate statin dose was associated with 48% lower 1-year mortality, again without interaction with gender.
conclusionsIn patients with chronic HF, female gender is independently associated with lower statin prescription rates and higher probability of inadequate dose. Statin therapy in these subjects is associated with improved 1-year survival in both men and women. This prognostic benefit is not affected by gender.
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