ArticleMetabolic brain disease2016
Sex differences and the role of PPAR alpha in experimental stroke.
Article in Metabolic brain disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 68 citations in OpenAlex.
- PPARMolecular nutrition & food research · 2026Article
- Exploring sex bias in cardiometabolic diseases.Lipids in health and disease · 2026Review
- Perinatal omega-3 sex-selectively mitigates neuropsychiatric impacts of prenatal THC in the cortico-striatal-hippocampal circuit.Molecular psychiatry · 2025Article
- Current View on PPAR-α and Its Relation to Neurosteroids in Alzheimer's Disease and Other Neuropsychiatric Disorders: Promising Targets in a Therapeutic Strategy.International journal of molecular sciences · 2024Review
- Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes.BMC pharmacology & toxicology · 2024Article
- Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes.bioRxiv : the preprint server for biology · 2023Article
- Sex differences in plasma lipid profiles of accelerated brain aging.Neurobiology of aging · 2023Article
- Bioactive Compounds for Customized Brain Health: What Are We and Where Should We Be Heading?International journal of environmental research and public health · 2023Review
- Anti-inflammatory role of fenofibrate in treating diseases.Biomolecules & biomedicine · 2023Review
- Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine.Frontiers in aging neuroscience · 2022Review
- Sex-based eRNA expression and function in ischemic stroke.Neurochemistry international · 2021Article
- Sensory Neurons, Neuroimmunity, and Pain Modulation by Sex Hormones.Endocrinology · 2021Review
- Differentially Expressed Genes and Their Clinical Significance in Ischaemic Stroke: An In-Silico Study.The Malaysian journal of medical sciences : MJMS · 2020Article
- Neurovascular protection by peroxisome proliferator-activated receptor α in ischemic stroke.Experimental neurology · 2020Review
- Methylation of Phospholipase A2 Group VII Gene Is Associated with Brain Arteriovenous Malformations in Han Chinese Populations.Journal of molecular neuroscience : MN · 2020Article
- Alzheimer's Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α.Cells · 2020Review
- Review
- Sex-regulated gene dosage effect of PPARα on synaptic plasticity.Life science alliance · 2019Article
- Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion.Journal of neuroinflammation · 2018Article
- A Systems Biology Approach to Investigating Sex Differences in Cardiac Hypertrophy.Journal of the American Heart Association · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Males and females respond differently to stroke. Moreover, females often experience worse long-term stroke outcomes. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARα) agonist has been shown to improve stroke outcome and resolve neuroinflammation in male mice. The present study compares the effect of pretreatment with fenofibrate versus vehicle control in male and female mice during experimental stroke. Mice were treated with low-dose fenofibrate 30 min before and once a day for three additional days after stroke onset. We observed a reduction in infarct volume in male mice 96 h post-stroke with low-dose fenofibrate pretreatment that was due to increase of an M2 macrophage phenotype in the brain and an increase in regulatory cells in the periphery. These outcomes were not replicated in females, likely due to the lower PPARα expression in cells and tissues in females vs males. We conclude that PPARα agonist treatment prior to stroke is neuroprotective in males but not females. These findings indicate PPARα as a probable mechanism of sex difference in stroke outcome and support the need for representation of females in stroke therapy research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.