ReviewFrontiers in pharmacology2015
In vivo small animal micro-CT using nanoparticle contrast agents.
Review in Frontiers in pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 151 citations in OpenAlex.
- Dynamic Evaluation of Vascular Remodeling and Aneurysm Progression Using Blood-Pool Contrast-Enhanced In Vivo Micro-CT in a Rodent Model.Journal of cardiovascular translational research · 2026Article
- Quantitative Preclinical Imaging as a Metrological Framework: Reproducibility, Validation, and Translational Maturity.Journal of imaging · 2026Review
- Protocol for Post-Mortem Micro-CT Imaging of Coronary Arteries in Low-Mass Neonatal Puppy Hearts Using Barium-Based Contrast.Animals : an open access journal from MDPI · 2026Article
- Potential of Silver Nanoparticles in Imaging Diagnostics and Image-Guided Applications: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Methods to localize cell specific alterations within the 3D context of the lung.Frontiers in physiology · 2026Review
- Evaluation of semicircular canal dehiscence using micro-computed tomography and comparison with cone-beam computed tomography.Anatomical science international · 2026Article
- Laser-Ablated Gold Nanoparticles as Tunable Contrast Agents for Preclinical Imaging.Nanomaterials (Basel, Switzerland) · 2025Article
- Thermoregulable Magnetic Microfluidic Devices by Magnetic Hyperthermia from Iron Oxide Nanoparticles.ACS applied nano materials · 2025Article
- Sectional Anatomy with Micro-Computed Tomography and Magnetic Resonance Imaging Correlation of the Middle and Caudal Abdominal Regions in the Syrian Hamster (Animals : an open access journal from MDPI · 2025Article
- The micro CT evaluation of crown and root pulp volume versus dentin thickness in teeth in postmortem interval (PMI).Forensic science, medicine, and pathology · 2025Article
- Comparative analysis of ocular biometrics using spectral domain optical coherence tomography with Purkinje image and optic nerve head alignments in mice.European journal of medical research · 2025Article
- The Emergence of Nanotechnology in the Prognosis and Treatment of Myocardial Infarctions.Recent patents on nanotechnology · 2025Review
- Contrast-enhanced photon-counting micro-CT of tumor xenograft models.Physics in medicine and biology · 2024Article
- Nanoparticulated Bimodal Contrast Agent for Ultra-High-Field Magnetic Resonance Imaging and Spectral X-ray Computed Tomography.Inorganic chemistry · 2024Article
- High-Spatial-Resolution Benchtop X-ray Fluorescence Imaging through Bragg-Diffraction-Based Focusing with Bent Mosaic Graphite Crystals: A Simulation Study.International journal of molecular sciences · 2024Article
- An optimized CT-dense agent perfusion and micro-CT imaging protocol for chick embryo developmental stages.BMC biomedical engineering · 2024Article
- Article
- Contrast-enhanced photon-counting micro-CT of tumor xenograft models.bioRxiv : the preprint server for biology · 2024Article
- Targeted Nanotheransotics: Integration of Preclinical MRI and CT in the Molecular Imaging and Therapy of Advanced Diseases.Nanotheranostics · 2024Review
- Magnetic Resonance Imaging as a Tool for Monitoring Intratibial Growth of Experimental Prostate Cancer Metastases in Mice.Methods and protocols · 2023Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Computed tomography (CT) is one of the most valuable modalities for in vivo imaging because it is fast, high-resolution, cost-effective, and non-invasive. Moreover, CT is heavily used not only in the clinic (for both diagnostics and treatment planning) but also in preclinical research as micro-CT. Although CT is inherently effective for lung and bone imaging, soft tissue imaging requires the use of contrast agents. For small animal micro-CT, nanoparticle contrast agents are used in order to avoid rapid renal clearance. A variety of nanoparticles have been used for micro-CT imaging, but the majority of research has focused on the use of iodine-containing nanoparticles and gold nanoparticles. Both nanoparticle types can act as highly effective blood pool contrast agents or can be targeted using a wide variety of targeting mechanisms. CT imaging can be further enhanced by adding spectral capabilities to separate multiple co-injected nanoparticles in vivo. Spectral CT, using both energy-integrating and energy-resolving detectors, has been used with multiple contrast agents to enable functional and molecular imaging. This review focuses on new developments for in vivo small animal micro-CT using novel nanoparticle probes applied in preclinical research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.