Evidence map›Paper›PMID 26581580›Full record

ArticleClimacteric : the journal of the International Menopause Society2016

Vulvar and vaginal atrophy in four European countries: evidence from the European REVIVE Survey.

R E Nappi, S Palacios, N Panay, M Particco, M L Krychman

Erratum issued 2 registry-linked trialsAbstract read
In one paragraph

Article in Climacteric : the journal of the International Menopause Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07250490 completednot on this mapstarted 2022, after this paper: background citation

Validation of the DIVAS-Q (Day to Day Impact of Vulvovaginal Atrophic Symptoms Questionnaire) A Portuguese Patient-Reported Outcome Measure

TypeobservationalSponsorInstituto Politécnico de LeiriaRan2022 to 2025Enrolled300ConditionsVulvovaginal Atrophy, Genital Disorder, PROMs
NCT07306611 phase1 / phase2completednot on this mapstarted 2024, after this paper: background citation

Regenerative Treatment of Female Genital Atrophy

TypeinterventionalSponsorAndreiaAntunesRan2024 to 2025Enrolled30ConditionsVulvo Vaginal AtrophyArmsMesotherapy with Autologous Platelet-Rich Plasma (PRP) to vulvovaginal area, Mesotherapy with saline solution, Platelet-Poor Plasma Gel
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 209 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 5 countries.

R E Nappia Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences , University of Pavia , Pavia , Italy ;
S Palaciosb Palacios Institute of Women's Health , Madrid , Spain ;
N Panayc Imperial College London , London , UK ;
M Particcod Shionogi Italy , Rome , Italy ;
M L Krychmane Southern California Center for Sexual Health and Survivorship Medicine Inc. , Newport Beach , CA , USA.
Foundation Center · USImperial College London · GBInstituto Palacios · ESShionogi (Japan) · JPSouthern California Reproductive Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of the European REVIVE survey was to achieve a better understanding of vulvovaginal atrophy (VVA), a chronic and progressive condition after menopause. We investigated perceptions, experiences and needs in terms of sexual and vaginal health in a sample of European postmenopausal women.

methodsAn online internet based survey was conducted in Italy, Germany, Spain and the UK with a total surveyed sample of 3768 postmenopausal women (age: 45-75 years).

resultsThe most common VVA symptom was vaginal dryness (70%). VVA has a significant impact on the ability to be intimate (62%), to enjoy sexual intercourse (72%) and to feel sexual spontaneity (66%). Postmenopausal women with VVA are sexually active (51%), but their sexual drive is reduced. Health-care professionals (HCPs) have discussed VVA with postmenopausal women (62%), but they initiated the conversation only in 10% of the cases. The most common treatments for VVA are over-the-counter, non-hormonal, local vaginal products. Thirty-two per cent of postmenopausal women were naïve to any kind of treatment, whereas discussion with the HCP was relevant to be on current treatment (60% of postmenopausal women that discussed VVA with a HCP vs. 23% who did not). The top reasons for poor compliance with vaginal treatments were: not bothersome enough symptoms (18%); vaginal changes not therapeutically reversed (18%); relief from VVA symptoms (17%). Approximately 45% were satisfied with treatment. The most frequent disliked aspects of treatment were the route of administration or the messiness. The fear of hormones was common in postmenopausal women using vaginal prescription products.

conclusionsThe European REVIVE survey confirmed that VVA symptoms are frequent in postmenopausal women and demonstrates a significant impact on quality of life and sexual life. However, the condition is still under-diagnosed and under-treated, with a high rate of dissatisfaction for actual available treatments in the four European countries surveyed. The discussion of symptoms with HCPs seems the most critical factor for diagnosis and treatment of VVA.

Indexed as

Health SurveysPostmenopauseAgedAtrophyDyspareuniaEuropeFemaleHumansMiddle AgedQuality of LifeSexual BehaviorVaginaVaginal DiseasesVulvadyspareuniaEuropepostmenopausal womenREVIVE Surveysexual relationshipstreatmentvaginal drynessVulvar and vaginal atrophy

Identifiers

PMID26581580
PMCPMC4819825
OpenAlexW2176311654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.