Evidence map›Paper›PMID 26581573›Full record

ArticleOpen biology2015

There is no 'Conundrum' of InsP6.

Robin F Irvine, Simon J Bulley, Miranda S Wilson, Adolfo Saiardi

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Human plasma inositol hexakisphosphate (InsPmicroPublication biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Robin F IrvineDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK rfi20@cam.ac.uk.
Simon J BulleyDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK Department of Haematology, Cambridge University Hospitals NHS Trust, Hills Road, Cambridge CB2 0QQ, UK.
Miranda S WilsonMedical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK.
Adolfo SaiardiMedical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK dmcbado@ucl.ac.uk.
Cambridge University Hospitals NHS Foundation Trust · GBMRC Laboratory for Molecular Cell Biology · GBUniversity College London · GBUniversity of Cambridge · GB

Funding

Medical Research Council MC_U122680443Medical Research Council MC_UU_12018/4
6 · The paper itself

Abstract

Indirect assays have claimed to quantify phytate (InsP6) levels in human biofluids, but these have been based on the initial assumption that InsP6 is there, an assumption that our more direct assays disprove. We have shown that InsP6 does not and cannot (because of the presence of an active InsP6 phosphatase in serum) exist in mammalian serum or urine. Therefore, any physiological effects of dietary InsP6 can only be due either to its actions in the gut as a polyvalent cation chelator, or to inositol generated by its dephosphorylation by gut microflora.

Indexed as

AnimalsHumansInositol PhosphatesPhytic AcidInositol PhosphatesPhytic Acid

Identifiers

PMID26581573
PMCPMC4680572
OpenAlexW2174682903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.